Living small animal imaging system and imaging method

Abstract

The invention discloses a living small animal imaging system in a miniature CT and fluorescent tomography dual mode and an imaging method thereof. The living small animal imaging system in the miniature CT and the fluorescent tomography dual mode comprises a main control computer, an X-ray source and an X-ray detection device, an excitation source and an excitation light / fluorescent light detection device, and a rotary scanning device, wherein the X-ray source and the X-ray detection device, the excitation source and the excitation light / fluorescent light detection device, and the rotary scanning device are controlled by the main control computer. The invention can simultaneously acquire structure information by carrying out the miniature CT imaging on a small animal and fluorescent-labeled molecular information by carrying out the fluorescent tomography on small animals to enable the molecular information acquired by the fluorescent tomography to be accurately positioned in the smallanimal, thereby being beneficial to improving the diagnosis accuracy.

Description

technical field [0001] The invention relates to the technical field of biomedical imaging, in particular to an imaging system and imaging method for living small animals. Background technique [0002] Molecular imaging is an imaging method emerging in recent years that can dynamically observe biological events at the cellular and molecular levels in small living animals. It can be applied to early diagnosis of cancer, dynamic detection of tumor growth and metastasis, development of new drugs, etc. Mainly use traditional medical instruments such as MRI (magnetic resonance imaging, magnetic resonance imaging), PET (positron emission tomography, positron emission tomography), SPECT (single photonemission computed tomography, single photon emission tomography), etc., combined with different Molecular probes for molecular imaging. Fluorescence tomography is a non-destructive optical tomography technology. Compared with traditional imaging methods, its advantages are that it is ...

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Problems solved by technology

Although fluorescence tomography can reconstruct fluorescent molecular markers in small animals, it cannot image the structure of small animal samples

Therefore, the molecular information obtained by pure fluorescence tomography cannot be accurately located in small animals.

This can easily lead to wrong diagnostic results (Ralf B. Schulz et al., Comparison of noncontact and fiber-based fluorescence-mediated tomography, "Optics Letters", 2006: 769-771)

Chinese Patent Publication No. CN 101057788A, published on October 24, 2007, the name of the invention is a fluorescent molecular tomography imaging device. Beam Scanning in 3D Space

Chinese Patent Publication No. CN 101317765A, published on December 10, 2008, the name of the invention is a dual-mode imaging system integrating nuclide imaging and fluorescence imaging. The application discloses positron emission tomography and fluorescence tomography The shortcoming of the dual-mode system integrated with the imaging system is that both imaging methods can provide molecular imaging results, but positron emission tomography cannot provide structural information of the sample, and the complementarity of the two imaging methods is not high

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