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Marine oligosaccharide compound with type II diabetes resisting activity and preparation method thereof

A technology for marine oligosaccharides and diabetes, which is applied in the direction of sugar compounds with non-glycosyl groups, preparation of sugar derivatives, organic active ingredients, etc., can solve problems such as unclear targets, low bioavailability, and poor oral absorption. Achieve the effect of good oral absorption, low molecular weight and high chromium binding rate

Active Publication Date: 2012-08-22
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many carbohydrate compounds have shown good application prospects in the prevention and treatment of diabetes, such as the research found that pumpkin polysaccharides and bitter gourd polysaccharides from plants, tremella polysaccharides, ganoderma lucidum polysaccharides and cordyceps polysaccharides from fungi, marine animal and plant sources Chitosan, fucoidan, and spirulina polysaccharides all have different degrees of hypoglycemic effects, but at present, the targets of these polysaccharides are not clear, and there are disadvantages such as poor oral absorption and low bioavailability, which limit their use in the field. clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 10g polymannuronic acid (weight average molecular weight is 7350 Daltons) and dissolve in 500ml pure water, adjust pH=10 with sodium hydroxide solution, add 2mol / L sodium hydroxide and 2mol / L chromium chloride solution, when green flocculent precipitates appear in the solution, stop adding sodium hydroxide and chromium chloride, and continue to keep warm for 1 hour. Take out the reaction solution, filter, concentrate the filtrate to 200mL, add 3 times the volume of 95% ethanol, precipitate, stand still, collect the precipitate, dehydrate with absolute ethanol, and dry under reduced pressure at 45°C to obtain a chromium content of about 15%. % Chromium polymannuronate complex.

Embodiment 2

[0015] Weigh 10g of polymannuronic acid (weight-average molecular weight: 5200 Daltons) and dissolve it in 500ml of pure water, adjust pH=8 with sodium carbonate solution, add 2mol / L sodium carbonate and 2mol / L sodium carbonate dropwise in a water bath at 70°C L chromium acetate solution 1mL, heat preservation reaction 1h. Take out the reaction solution, filter, concentrate the filtrate to 200mL, add 3 times the volume of acetone, precipitate, stand still, collect the precipitate, dehydrate with acetone, and dry under reduced pressure at 45°C to obtain polymannose with a chromium content of about 1%. Chromium uronic acid complex.

Embodiment 3

[0017] Weigh 10g of polymannuronic acid (weight-average molecular weight: 1500 Daltons) and dissolve it in 500ml of pure water, adjust the pH to 5, add 2mol / L sodium hydroxide and 2mol / L chromium nitrate dropwise in a water bath at 60°C Solution 5mL, insulation reaction 1h. Take out the reaction solution, filter, concentrate the filtrate to 200mL, add 4 times the volume of acetone, precipitate, stand still, collect the precipitate, dehydrate with acetone, and dry under reduced pressure at 45°C to obtain polymannose with a chromium content of about 5%. Chromium uronic acid complex.

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PUM

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Abstract

The invention relates to a marine oligosaccharide compound with type II diabetes resisting activity, which is a compound which is formed by following steps: taking D-polymannose aldehydic oligosaccharide which comes from sea and contains carboxyl in each oligosaccharide ring, reacting with dilute alkali and chromium salt solution and introducing trivalent chromium ions which is closely relative to the generation and the development of diabetes into oligosaccharide molecules. A pharmacological experiment proves that the product has remarkable effect on accelerating insulin secretion, is not influenced by amylin and has effects on lightening glucose load, improving blood-lipoid metabolism, insulin sensitivity and certain kidney protection and lightening pancreatic injury for type II diabetes rats and mouse. The product of the invention comes from marine natural species, has the advantages of good security, unique structure, low molecular weight, high chromium binding ratio, good oral absorption effect, and the like, can play a hypoglycemic role in a plurality of links and has favorable market application prospect on the aspect of preventing and treating type II diabetes.

Description

technical field [0001] The present invention relates to a compound having antidiabetic activity. Specifically, it relates to a polymannuronate chromium complex derived from marine brown algae, its preparation method and its application in anti-type II diabetes. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disease with multiple etiologies. According to the statistics of the International Diabetes Federation in 2007, the total number of diabetic patients in the world has reached 246 million, of which type II diabetes accounts for more than 90% of the total diabetic patients. It is estimated that about 6 people die of diabetes every minute in the world. The number of deaths due to diabetes and its complications is second only to cancer and cardiovascular and cerebrovascular diseases, and has become the third largest killer affecting human life and health. At present, the clinically used antidiabetic drugs mainly include biguanides, sulfo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/04C07H7/033C07H1/00A61K31/734A61P3/10A61P5/50
Inventor 赵峡于广利管华诗李广生郝翠
Owner OCEAN UNIV OF CHINA
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