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Core-shell type magnetic nano-composite particle based on Fe3O4 and houghite and preparation method thereof

A composite particle, magnetic nanotechnology, applied in the direction of inorganic material magnetism, non-active ingredients medical preparations, medical preparations containing active ingredients, etc., can solve the influence of uneven particle size, incomplete core-shell structure, difficult to control Particle size and other issues, to achieve uniform distribution, good drug release effect, strong magnetic effect

Inactive Publication Date: 2010-02-17
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of Fe 3 o 4 The core-shell magnetic nanocomposite particles with magnesium aluminum hydrotalcite and its preparation method solve the problems of uneven particle size of general magnetic targeting drug preparations, difficulty in controlling particle size and incomplete core-shell structure affecting pharmacological stability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Fe 3 o 4 preparation and surface modification

[0028] Weigh FeCl 3 ·6H 2 O and sodium acetate, added to 400ml ethylene glycol and stirred at room temperature until dissolved to form a uniformly dispersed yellow solution, in which FeCl 3 ·6H 2 The molar concentration of O is 0.0125mol / L, sodium acetate and FeCl 3 ·6H 2 The molar concentration ratio of O is 4.24. The resulting solution was charged into a 500 ml autoclave, followed by crystallization at 200° C. for 8 hours. The autoclave was taken out and naturally cooled to room temperature, and the obtained Fe 3 o 4 The suspension was washed three times each with ethanol and deionized water, and the Fe and Fe boron permanent magnets were used to separate the Fe 3 o 4 solid. After washing, the obtained Fe 3 o 4 The solid was redispersed in ethanol and stored in a ground flask until use. The Fe obtained by the above steps 3 o 4 The particle size is 100nm, and the specific saturation magnetization σ s...

Embodiment 2

[0036] (1) Fe 3 o 4 preparation and surface modification

[0037] Weigh FeCl 3 ·6H 2 O and sodium acetate, added to 400ml ethylene glycol and stirred at room temperature until dissolved to form a uniformly dispersed yellow solution, in which FeCl 3 ·6H 2 The molar concentration of O is 0.025mol / L, sodium acetate and FeCl 3 ·6H 2 The molar concentration ratio of O is 4.24. The resulting solution was charged into a 500 ml autoclave, followed by crystallization at 200° C. for 8 hours. The autoclave was taken out and naturally cooled to room temperature, and the obtained Fe 3 o 4 The suspension was washed three times each with ethanol and deionized water, and the Fe and Fe boron permanent magnets were used to separate the Fe 3 o 4 solid. After washing, the obtained Fe 3 o 4 The solid was redispersed in ethanol and stored in a ground flask until use. The Fe obtained by the above steps 3 o 4 The particle size is 150nm, and the specific saturation magnetization σ s ...

Embodiment 3

[0045] (1) Fe 3 o 4 preparation and surface modification

[0046] Weigh FeCl 3 ·6H 2 O and sodium acetate, added to 400ml ethylene glycol and stirred at room temperature until dissolved to form a uniformly dispersed yellow solution, in which FeCl 3 ·6H 2 The molar concentration of O is 0.1mol / L, sodium acetate and FeCl 3 ·6H 2 The molar concentration ratio of O is 4.24. The resulting solution was charged into a 500 ml autoclave, followed by crystallization at 200° C. for 8 hours. The autoclave was taken out and naturally cooled to room temperature, and the obtained Fe 3 o 4 The suspension was washed three times each with ethanol and deionized water, and the Fe and Fe boron permanent magnets were used to separate the Fe 3 o 4 solid. After washing, the obtained Fe 3 o 4 The solid was redispersed in ethanol and stored in a ground flask until use. The Fe obtained by the above steps 3 o 4 The particle size is 260nm, and the specific saturation magnetization σ s 85...

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Abstract

The invention relates to a core-shell type magnetic nano-composite particle based on Fe3O4 and houghite and a preparation method thereof, belonging to the technical field of magnetic nano material technology and drug slow / control release technology. The magnetic nano-composite particle has a typical core-shell structure. The preparation method comprises the following steps: preparing a nano ferroferric oxide particle with a controllable particle diameter and even distribution in advance by adopting a solvent thermal method, and then coating a layer of organic carbon being rich in hydroxy on the surface of the particle; further coating inorganic anion intercalation houghite with different thickness on the surface of the particle through coprecipitation self assembly, obtaining a magnetic control targeting drug carrier with the core-shell structure through baking, and then obtaining a magnetic drug-loaded nano-particle having the core-shell structure and the slow / control release performance by means of a structure memory effect load antiinflammatory agent or anticarcinogen with a houghite structure. The invention has the advantages that the prepared novel magnetic nanocomposite particle has even particle diameter distribution and integrated core-shell structure.

Description

technical field [0001] The invention belongs to the technical fields of magnetic nanomaterial technology and drug sustained and controlled release, and in particular relates to a Fe 3 o 4 A core-shell magnetic nanocomposite particle of magnesium aluminum hydrotalcite and a preparation method thereof. Background technique [0002] In recent years, functionalized magnetic nanocomposites, especially magnetic nano drug-loaded particles, have attracted extensive attention in biomedicine (M.De, P.S. et al., Adv. Mater., 2008, 20, 1-17). After the magnetic nano drug-loaded particles enter the human body through injection or oral administration, a magnetic field of a certain strength is applied outside the lesion. Using the inductive properties of the magnetic field, it can avoid the phagocytosis of macrophages in the reticuloendothelial system and make the magnetic drug carrier Aggregation localizes to the lesion site. Subsequently, the drug is released in a variety of ways, con...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/02A61K47/48A61K31/192A61K31/196A61K31/7072H01F1/34H01F1/36B22F1/02A61K47/69
Inventor 张慧盘登科范婷陈建刚
Owner BEIJING UNIV OF CHEM TECH
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