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Preparation method of biological active glass/chitosan composite porous support material

A bioactive glass and porous scaffold technology, applied in the field of biomedical materials, can solve the problems of insufficient mechanical strength of porous scaffold materials, no industrial application, and difficulty in meeting the requirements of providing support for tissue defects, so as to facilitate cell adhesion and proliferation, The process parameters are easy to control and the effect of the appropriate pore size

Inactive Publication Date: 2010-02-10
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the preparation of sol-gel bioglass porous scaffold materials by this method, let alone any reports on industrial applications.
The main reason is that the mechanical strength of the prepared porous scaffold material is not enough, and it is difficult to meet the requirements of providing support for tissue defects.

Method used

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  • Preparation method of biological active glass/chitosan composite porous support material
  • Preparation method of biological active glass/chitosan composite porous support material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing a bioactive glass / chitosan composite porous scaffold material uses a perfusion method to compound chitosan and a sol-gel bioglass porous scaffold material prepared by a foam impregnation method, including the following steps and process conditions:

[0029] Step 1: Preparation of pure bioactive glass scaffold materials by foam impregnation method

[0030] (1) CaO-P prepared by sol-gel method 2 o 5 -SiO 2 It is a bioactive glass ball milled and sieved, and the bioactive glass powder with a particle size not greater than 15 μm is taken for use;

[0031] (2) Add 3 parts by weight of polyvinyl alcohol to 100 parts by weight of deionized water as a binder, heat in a constant temperature water bath at 80°C, and stir vigorously for 2 hours. After the binder is completely dissolved, add 50 parts by weight The sieved bioactive glass powder with a particle size not greater than 15 μm was vigorously stirred for 2 hours to make a slurry, and the obtained s...

Embodiment 2

[0040] A method for preparing a bioactive glass / chitosan composite porous scaffold material uses a perfusion method to compound chitosan and a sol-gel bioglass porous scaffold material prepared by a foam impregnation method, including the following steps and process conditions:

[0041] Step 1: Preparation of pure bioactive glass scaffold materials by foam impregnation method

[0042] (1) CaO-P prepared by sol-gel method 2 o 5 -SiO 2 It is a bioactive glass ball milled and sieved, and the bioactive glass powder with a particle size not greater than 15 μm is taken for use;

[0043] (2) Add 5 parts by weight of polyvinyl alcohol to 100 parts by weight of deionized water as a binder, heat in a constant temperature water bath at 70°C, and stir vigorously for 1 hour. After the binder is completely dissolved, add 30 parts by weight The sieved bioactive glass powder whose particle size is not greater than 15 μm is vigorously stirred for 1 hour to make a slurry, and the obtained slur...

Embodiment 3

[0051] A method for preparing a bioactive glass / chitosan composite porous scaffold material uses a perfusion method to compound chitosan and a sol-gel bioglass porous scaffold material prepared by a foam impregnation method, including the following steps and process conditions:

[0052] Step 1: Preparation of pure bioactive glass scaffold materials by foam impregnation method

[0053] (1) CaO-P prepared by sol-gel method 2 o 5 -SiO 2 It is a bioactive glass ball milled and sieved, and the bioactive glass powder with a particle size not greater than 15 μm is taken for use;

[0054] (2) Add 4 parts by weight of carboxymethyl cellulose or starch to 100 parts by weight of deionized water as a binder, heat in a constant temperature water bath at 90°C, and stir vigorously for 1.5 hours until the binder is completely dissolved , adding 40 parts by weight of sieved bioactive glass powder with a particle size not greater than 15 μm, stirring vigorously for 2 hours to make a slurry, ...

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Abstract

The invention discloses a preparation method of biological active glass / chitosan composite porous support material, which adopts a perfusion method to compound chitosan and sol-gel biological glass porous support material prepared by a foam impregnation method. The invention comprises the steps of preparing pure biological active glass support material through the foam impregnation method, preparing chitosan solution and compounding biological active glass / chitosan composite support through the perfusion method, wherein the preparation of pure biological active glass support material through the foam impregnation method comprises preparation of size of the biological active glass, selection, impregnation and desiccation of polyurethane foam template.. During the preparation process of theinvention, shape, porosity and distribution of aperture are easy to be regulated and controlled. The prepared support material is provided with three-dimensional reticulate backbone structure, and themechanical intensity, biocompatibility and bioactivity thereof are excellent and degradable; the pressure strength thereof can achieve 1.15-1.30 MPa; apparent porosity can achieve 70%-80%. The support material is capable of meeting the requirements of providing support for defective parts of tissue. The invention has simple and practical method, thus being easy for large-scale production.

Description

technical field [0001] The invention relates to the preparation technology of an artificial bone repair material in the field of biomedical materials, in particular to a preparation method of a bioactive glass / chitosan composite porous support material. Background technique [0002] With the increasing demand for bone defect repair in clinical medicine at home and abroad, a lot of research progress has been made in the field of biocomposites at home and abroad. In recent years, the research on the problems of traditional bone repair materials has developed rapidly. Although bioactive glass is an inorganic bioactive material with excellent biocompatibility and bioactivity, it can rapidly undergo a series of surface reactions at the implant site to form hydroxyphosphorus carbonate that is well combined with bone and soft tissue. Limestone layer, but it does not have a three-dimensional porous structure, so it is not the most ideal scaffold material for bone tissue repair. Be...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/54A61L27/56A61L27/10A61L27/20
Inventor 陈晓峰谢林王迎军孟永春苗国厚赵娜如
Owner SOUTH CHINA UNIV OF TECH
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