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High affinity combined sites of hgfr and method for identifying its antagonist

A domain, hepatocyte growth factor technology, applied in the field of hepatocyte growth factor receptor protein, can solve problems such as hindering the separation of therapeutic drugs

Inactive Publication Date: 2010-01-06
METHERESIS TRANSLATIONAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This may hinder the isolation of more selective therapeutics with enhanced sensitivity and fewer side effects

Method used

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  • High affinity combined sites of hgfr and method for identifying its antagonist
  • High affinity combined sites of hgfr and method for identifying its antagonist
  • High affinity combined sites of hgfr and method for identifying its antagonist

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Embodiment Construction

[0020] The invention will be described in detail in some related preferred embodiments by way of non-limiting examples with reference to the accompanying drawings, in which:

[0021] figure 1 Met and HGF subdomains are shown Genetic engineering and purification. (A) Schematic representation of the genetically engineered proteins used in this study. Left: Genetically engineered receptors. W.T.MET, wild-type Met; EXTRA, extracellular part; INTRA, intracellular part; SP, signal peptide; SEMA, semaphorin homology domain; PSI, plexin-semaphorin-integrin homology domain; IPT1- 4, Immunoglobulin-plexin-transcription factor homology domain 1-4; TM, transmembrane region; JM, membrane juxtaposition; KD, kinase domain; CT, C-terminal tail; E, FLAG or MYC epitope; H, Polyhistidine tag. Red triangles indicate the proteolytic cleavage site between the α and β chains. Right: Genetically engineered ligands. W.T.HGF, wild-type HGF; ND, N-terminal domain; K1-4, kringle 1-4; PLD, proteol...

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Abstract

The invention discloses a use for screening and developing a medicine effectively useful in the pharmacologia by encoding or containing polynucleotide or polypeptide in at least IPT-3 and IPT-4 structure domain outside the receptor cell of the hepatocyte growth factor, and preferably for treating cancer caused by hepatocyte growth factor receptor misadjusting.

Description

field of invention [0001] The present invention relates to the field of hepatocyte growth factor receptor (HGFR) proteins. More specifically, the present invention relates to methods of identifying high affinity binding sites for HGFR and its ligand, hepatocyte growth factor (HGF), and HGFR antagonists that target the high affinity binding sites of HGFR. Background of the invention [0002] Hepatocyte growth factor receptor (also known as Met) is a tyrosine kinase and is the product of the c-met proto-oncogene. It consists of a 50 kDa α subunit and a 145 kDa β subunit connected by a disulfide bond, the α subunit is completely extracellular while the β subunit includes (from N-terminus to C-terminus) an extracellular domain , a transmembrane domain and a cytoplasmic tyrosine kinase domain. The mature α / β heterodimeric receptor is generated from a 170 kDa single-chain precursor by proteolytic processing and terminal glycosylation. [0003] HGF, also known as Scatter Factor,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G01N33/68G01N33/574G01N33/566C12Q1/02A61K38/17A61K48/00A61P35/00
CPCB60R2021/01211B60R21/2342B60R21/01546B60R2021/01554B60R21/015B60R2021/23384
Inventor 保罗·玛丽亚·科莫格里奥保罗·卡米那提保罗·米切尼克里斯缇娜·巴西利克
Owner METHERESIS TRANSLATIONAL RES
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