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Application of strong brain-refreshing essence tablet in preparing medicine preventing and treating osteoporosis

A powerful technology for osteoporosis, applied in the field of medicine, can solve the problems of increased bone mineral content in osteoporosis model animals, and the discovery of strong Naoqingsu tablets, etc., to achieve stable and controllable quality, prevention and human sex hormone levels Effect of reducing and anti-aging gonadal function

Inactive Publication Date: 2010-01-06
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to literature search, at present, it has not been found that Qiangli Naoqingsu Tablets can prevent and treat osteoporosis, improve the bone density of osteoporosis model animals, increase bone mineral content, etc.

Method used

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  • Application of strong brain-refreshing essence tablet in preparing medicine preventing and treating osteoporosis
  • Application of strong brain-refreshing essence tablet in preparing medicine preventing and treating osteoporosis
  • Application of strong brain-refreshing essence tablet in preparing medicine preventing and treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0007] Example 1. Experimental study on the efficacy of strong naresin for sedation, tranquilization, hypoxia resistance, fatigue resistance, and sexual function enhancement

[0008] 1 Materials and methods

[0009] 1.1 Experimental animals NIH mice are provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine, certificate number: 2003A004, the room temperature is controlled at 24-28°C, and the humidity is controlled at 70-85%. 1.2 Drugs and reagents Strong Naoqingsu, provided by Guangzhou Baiyunshan Hutchison Whampoa Traditional Chinese Medicine Co., Ltd., batch number: 020711. Guilu Bushen Pills, provided by Guangdong Huatianbao Pharmaceutical Co., Ltd., batch number: 20020814.

[0010] 1.3 Experimental equipment Micropipette, GERSON; handheld electronic scale, HL-200, South Korea; analytical balance, GF-200, Japan; centrifugal precipitator, Shanghai Medical Instrument Factory; , Beijing Medical Equipment Factory.

[0011] 1.4 Expe...

example 2

[0039] Example 2. Prevention and treatment effect of Qiangli Naoqingsu Tablets on ovariectomized osteoporosis rats

[0040] 2. Materials and methods

[0041] Material

[0042] (1) Drugs

[0043] The present invention is provided by Guangzhou Baiyunshan Hutchison Whampoa Traditional Chinese Medicine Co., Ltd., new technology batch number: 070512,

[0044] Positive drug oyster calcium carbonate tablets, Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd., batch number: T32016;

[0045] IL-6 detection kit, provided by the Liberation Army General Hospital Science and Technology Development Center, batch number: 070330;

[0046] E2 detection kit, provided by Beijing Kemei Dongya Biotechnology Co., Ltd., batch number: 070325.

[0047] (2) As animals, 72 32-week-old, clean, SD female rats with a body weight of (380±20 g) were selected and provided by the Experimental Animal Center of Sun Yat-sen University of Medical Sciences. Feed with common feed, refer to the AIN-93M roden...

example 3

[0074] Example 3 Clinical Observation on Treating Osteoporosis with Strong Naoqingsu

[0075] 1. Clinical research

[0076] 1.1 Clinical data

[0077] 1.1.1 Diagnostic criteria of western medicine Osteoporosis is defined as a decrease of more than 2 standard deviations (SD) compared with the peak bone mineral density of local women. This study refers to the lumbar bone mineral density of Chinese adults, and the peak value for females is 1.004±0.107g / cm 2 , in the 30-40 age group, the standard deviation is 0.107, so 0.790g / cm 2 It is the diagnostic standard of osteoporosis, below this value is the patient with osteoporosis. Secondary osteoporosis, idiopathic osteoporosis and those who had taken drugs affecting bone metabolism within 3 months were excluded.

[0078] 1.1.2 Diagnostic criteria of traditional Chinese medicine ①Soreness of waist and spine; ②Soreness of shins and knees; Low libido; ③Tinnitus and deafness; Or purple tongue. Those who have the above-mentioned ①②③...

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Abstract

The invention discloses a novel medical application of a strong brain-refreshing essence tablet, which in particular relates to an application of the strong brain-refreshing essence tablet in preparing a medicine preventing and treating osteoporosis. The application comprises application in preparing a traditional Chinese medicine for improving the bone density of an osteoporosis model animal and increasing the bone and mineral contents and application in preparing a medicine for preventing the drop of the sexual hormone level of an old-aged animal and a person, resisting senility and enhancing the sexual gland function.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Qiangli Naoqingsu Tablets in the preparation of medicines for preventing and treating osteoporosis. Background technique [0002] Qiangli Naoqingsu, also known as Gengniankang, is one of the famous and excellent Chinese patent medicines. It is a tablet made of four medicines: Acanthopanax, Schisandra, pilose antler, and sodium glycerophosphate. In every 50ml of schisandra liquid extract in the prescription, there are 126-157 weight units of Acanthopanax sciatica extract, 2.8 weight units of velvet antler, and 35 weight units of sodium glycerophosphate. Clinically, it is mainly used for invigorating the kidney and strengthening the spleen, nourishing the heart and calming the nerves, palpitations, insomnia, loss of appetite, fatigue, frequent urination, impotence, neurasthenia, non-organic sexual function decline and women's menopausal syndrome caused by defi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61P19/10A61K31/661A61K35/32
Inventor 覃仁安李楚源黄竹英罗佩霞蔡越冬李淑如
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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