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Traditional Chinese medicine composition for treating hepatitis and liver cancer

A technology of composition and traditional Chinese medicine, which is applied in the direction of drug combination, antineoplastic drugs, and pharmaceutical formulas. It can solve problems such as unsatisfactory results, and achieve the effects of increasing glutathione levels, improving curative effect, and prolonging the action time.

Inactive Publication Date: 2009-12-30
NO 2 CLINICO MEDICINE COLLEGE GUANGZHOU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, surgical treatment is generally advocated, but less than 15% of all patients with liver cancer meet the indications for surgery. Drug treatment is still an indispensable means to prolong the life of patients. However, because the liver is a metabolic organ in the body, it has rich drug metabolism. Enzymes and protective efflux pumps, it is difficult for drugs to enter the liver and be stored to exert their effects, so the results of drug treatment are very unsatisfactory

Method used

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  • Traditional Chinese medicine composition for treating hepatitis and liver cancer
  • Traditional Chinese medicine composition for treating hepatitis and liver cancer
  • Traditional Chinese medicine composition for treating hepatitis and liver cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 24 grams of vinegar bupleurum is extracted with water, concentrated into extract, add 10 grams of rhein (purity ≥ 80%) (20 grams of rhubarb or 25 grams of rhubarb anthraquinone), 40 grams of quercetin (40 grams of rutin or golden silk 50 grams of atherin, added with auxiliary materials such as starch, microcrystalline cellulose, lactose or other fillers, is prepared into capsules or compressed into tablets.

Embodiment 2

[0039] Crush 3 grams of Bupleurum bupleurum into fine powder, add 50 grams of rhein (purity ≥ 80%) (60 grams of rhubarb or 70 grams of rhubarb anthraquinone), 20 grams of quercetin (30 grams of rutin or 40 grams of hyperin) , adding auxiliary materials such as starch, microcrystalline cellulose, lactose or other fillers and glidants to prepare tablets, capsules or pills.

Embodiment 3

[0041] Crush 60 grams of bupleurum bupleurum into coarse powder, add ethanol to extract and concentrate, add 60 grams of rhein (100 grams of rhubarb or 80 grams of rhubarb anthraquinone), 10 grams of quercetin (15 grams of rutin or 20 grams of hyperin), Add auxiliary materials such as starch, microcrystalline cellulose, hydroxypropyl methylcellulose, lactose and other fillers and glidants to prepare various dosage forms.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating hepatitis and liver cancer, comprising the following raw material medicines according to parts by weight: 1 to 120 parts of rhein or rhubarb class substances capable of being metabolized into the rhein in vivo, 1 to 50 parts of quercetin or quercetinic acid glucoside class substances capable of metabolized into the quercetinic acid in vivo and 3 to 60 parts of vinegar radix bupleuri, wherein the rhein is a market-sold product artificially synthesized or naturally extracted, and the purity is more than or equal to 80%. The composition can be prepared into various traditional Chinese medicine preparation medicines which can suppress the multiplication of liver cancer cells and promote the death of the liver cancer cells; an animal experiment validates that compared with the original anticancer medicine, the medicine can greatly enhance the concentration of the medicine in the liver and prolong the detention time of the medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating hepatitis and liver cancer. Background technique [0002] Hepatitis B is a high-incidence disease in China. About 20% of the population suffers from hepatitis B, and about 5% will eventually develop into liver cancer. There are about 500,000 liver cancer patients in my country every year, which seriously threatens human health. At present, surgical treatment is generally advocated, but less than 15% of all patients with liver cancer meet the indications for surgery. Drug treatment is still an indispensable means to prolong the life of patients. However, because the liver is a metabolic organ in the body, it has rich drug metabolism. Enzymes and protective efflux pumps make it difficult for drugs to enter the liver and retain them to exert their effects, so the results of drug treatment are not ideal. Contents of the invention [0003] The object of the invention is to p...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K36/708A61P1/16A61P31/14A61P31/20A61P35/00A61K31/122A61K31/192A61K31/352A61K31/7048
Inventor 赵瑞芝刘少军袁东陈有军刘丽娟赵莹
Owner NO 2 CLINICO MEDICINE COLLEGE GUANGZHOU UNIV OF TRADITIONAL CHINESE MEDICINE
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