Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound bismuth composition and preparation method thereof

A technology of compound bismuth and composition, which is applied in the field of medicine, can solve problems such as unsatisfactory release and affect the treatment effect of Helicobacter pylori in the stomach, and achieve the effects of simple design, reduced cost and improved production efficiency

Active Publication Date: 2009-12-23
SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
View PDF8 Cites 24 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since antibiotics and antibacterial agents are enteric-coated, their release in the stomach is not ideal, thus affecting the therapeutic effect on Helicobacter pylori in the stomach

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 125 g of metronidazole, 125 g of tetracycline hydrochloride, 20 g of sodium carboxymethyl starch, 45 g of pregelatinized starch, and 5 g of magnesium stearate were passed through a 100-mesh sieve respectively. Get sieved metronidazole, tetracycline hydrochloride, 60% by weight of sieved carboxymethyl starch sodium, and sieved pregelatinized starch and mix evenly, with 10% starch slurry as a binding agent to prepare Soft material, granulated through a 20-mesh sieve. Dry at 40-60°C and granulate. After sizing, add remaining 40% by weight of sieved sodium carboxymethyl starch and sieved magnesium stearate, and mix well. Press into small pieces with a diameter of 3mm.

[0037] Dosage of Opadry II (purchased from Colorcon) = uncoated tablet weight × 3%. Accurately weigh the required amount of Opadry II, add water to the liquid mixing container, and stir while adding. After adding all the ingredients, reduce the stirring speed to make the vortex disappear, and continue st...

Embodiment 2

[0040] Compound bismuth capsules were prepared in the same manner as in Example 1, except that 5 g of omeprazole was also added when the coated tablets were prepared.

Embodiment 3

[0042] Compound bismuth capsules were prepared in the same manner as in Example 1, except that insoluble bismuth subcarbonate was used instead of soluble colloidal bismuth pectin.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a compound bismuth composition which contains antibiotics, a coated tablet of antibacterial agent and bismuth particle or powder, wherein the coated tablet is coated with Opadry II and the coating amount is 3 percent by weight; and the weight ratio of bismuth to the antibiotics to the antibacterial agent is 4-35:5-50:5-50. The invention also discloses a preparation method of the compound bismuth composition. The compound bismuth composition achieves good balance between the mutual action among active ingredients and the action of the active ingredients performed in stomach, and therefore is used for better eliminating the helicobacter pylori of stomach.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound bismuth composition and a preparation method thereof. Background technique [0002] The presence of Helicobacter pylori affects the digestive system, such as prone to gastritis and gastroduodenal ulcers, which may form tumors in due course. Currently there is no single drug that can effectively eradicate Helicobacter pylori, so a combination of drugs is necessary. The usual treatment for these diseases is triple therapy or quadruple therapy. The method generally takes bismuth plus antibiotics and antibacterial agents as a treatment plan, and sometimes H 2 Receptor antagonists or proton pump inhibitors. [0003] US patent US 5196205 describes a method of treatment of the disease comprising the administration of bismuth-containing compounds, antibiotics belonging to the penicillin or tetracycline class, and antibacterial agents of the metronidazole class. Its treatment regime...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/732A61K33/24A61K9/48A61K9/28A61K9/16A61K9/14A61P31/04A61P1/04
Inventor 何仲贵姚娟娟王绍杰杨福安吴月侠穆清苏
Owner SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com