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Preparation of compound of cycloartenyl ferulate and purification process thereof

A technology of pineapple enol ferulate ester and composition, which is applied in the purification process and preparation field of pineapple enol ferulate ester, and achieves the effects of high yield, reduced technical difficulty, cost expenditure, and low cost

Active Publication Date: 2009-12-09
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The present invention solves the problem that the current technical field does not obtain the cycloartenyl ferulic acid ester scheme from oryzanol, and the disclosed technology uses the oryzanol medicine of the current standard as Raw materials, through modern separation and refining means, remove the non-cycloartenol ferulic acid ester components in most of the oryzanol raw materials, so as to obtain cycloarenol ferulic acid esters with a purity of more than 80% (including 80%)

Method used

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  • Preparation of compound of cycloartenyl ferulate and purification process thereof
  • Preparation of compound of cycloartenyl ferulate and purification process thereof
  • Preparation of compound of cycloartenyl ferulate and purification process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Get 1 kg of oryzanol containing about 40% cycloarneol ferulate, heat and dissolve with 15 kg of ethyl acetate, leave it at room temperature until crystals are precipitated, filter, and dry. Repeat the above process for 10 times with the dried crystals to obtain a reference substance with a content of cycloartenol ferulic acid ester of more than 99%.

Embodiment 2

[0034] 1. Chromatographic conditions and system suitability test: octadecylsilane bonded silica gel is used as filler; methanol-acetonitrile (40:60) is used as mobile phase; flow rate is 1.5ml / min; detection wavelength is 327nm; sensitivity is 0.005 AUFS. The number of theoretical plates should not be less than 2000 according to the calculation.

[0035] 2. Preparation of the test solution: Accurately weigh 10 mg of the commercially available oryzanol raw material and 10 mg of the present invention, put them in a 10 ml measuring bottle, add water to dissolve and constant volume, and shake well to obtain the test solution.

[0036] 3. Determination: Accurately draw 10 μl of the test solution, inject it into a liquid chromatograph, record the chromatogram, and check the percentage content of each component by the area normalization method.

[0037] 4. Measurement results

[0038] Table 2 Measurement results

[0039]

[0040] Illustrate that technique of the present inventi...

Embodiment 3

[0042] prescription

[0043] 1000 bottles of freeze-dried powder of the present invention for injection (containing 18mg / bottle of the present invention):

[0044] Purified product of the present invention 18g

[0045] Macrogol 400 250g

[0046] Tween 80 250g

[0047] 10% Mannitol 6000g

[0048] Add water for injection to 5000ml

[0049]

[0050] A total of 1000 tubes were freeze-dried

[0051] In the prescription, the raw material of the present invention is used as the main agent, Tween 80 is used as a solubilizing agent, polyethylene glycol 400 is used as a cosolvent, mannitol is used as a proppant, and water for injection is used as a freeze-drying solvent.

[0052] Preparation process

[0053] Take by weighing the purified product of the present invention, Tween-80, PEG-400, mannitol and 80% of the prescription amount of water for injection, stir to make it dissolve until the solution is clear, stir at room temperature f...

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Abstract

The invention discloses a technical scheme for preparing cycloartenyl ferulate from raw material of oryzanol and further discloses the application of the prepared cycloartenyl ferulate and surfactant to medicinal compound and preparation. Due to the purification process of the cycloartenyl ferulate by recrystallization, the purity of the cycloartenyl ferulate can achieve over 80%. The invention also discloses injection of the compound, particularly freeze-dried powder injection.

Description

technical field [0001] The invention discloses a purification process and preparation of cycloartenol ferulate. Further, the invention discloses a process for purifying cycloartenol ferulate from oryzanol raw materials by using recrystallization technology. Background technique [0002] With the gradual acceleration of the pace of life and work in modern society, the sub-health status of modern urbanites is not optimistic. According to statistics, patients with autonomic disorders, menopausal syndrome, primary dysmenorrhea, premenstrual tension, etc. due to autonomic dysfunction, lead to the imbalance of sympathetic and parasympathetic nerves, and the incidence of non-organic diseases is increasing year by year. trend. [0003] Autonomic disorders are usually caused by mental trauma, long-term tension and fatigue, which lead to weakening of the function of the cerebral cortex, excessive excitement and rapid fatigue. Menopausal syndrome mostly refers to the dysfunction of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K9/08A61P25/00
Inventor 郝守祝何乐张建平
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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