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Method for extracting dioscin

A technology of diosgenin and extraction method, which is applied in the field of extraction of dioscin, can solve the problems of long extraction time (several hours to more than ten hours, not suitable for industrialized large-scale production, large amount of solvent, etc.), shorten the infiltration time, and promote comprehensive Utilization, good social benefits and economic benefits

Inactive Publication Date: 2009-12-02
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But use organic solvent (such as methyl alcohol, ethanol etc.) or the aqueous solution of organic solvent to carry out leaching mostly in the method that adopts at present for the extraction of diosgenin, as the patent of invention that application number is 200510022745.9 and the patent of invention that patent number is 03144208.0 all It adopts methanol or ethanol to leaching, and the above-mentioned methods all have the disadvantages of long extraction time (several hours to more than ten hours), large amount of solvent, high cost, high energy consumption, low efficiency, etc., and are not suitable for large-scale industrial production; in addition, The used organic solvents (such as methanol, ethanol) are toxic, volatile, and less safe

Method used

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  • Method for extracting dioscin

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Embodiment 1

[0021] The method of this embodiment comprises the following steps: wash, dry and crush the rhizome of Dioscorea chinensis to 80 meshes, weigh 5.00 g of dry powder, add an aqueous solution of sodium lauryl sulfate with a mass fraction of 3.0%, and the liquid-solid ratio is The ratio of solvent to dry powder is 8:1, and ultrasonic extraction with a frequency of 20KHz and a power of 60W is used for 20 minutes, and the solid is separated to obtain an extract; HCl is added to the extract and heated and hydrolyzed to obtain crude diosgenin, and the obtained diosgenin is determined The yield was 1.86%.

Embodiment 2

[0023] The method of the present embodiment comprises the following steps: cleaning the rhizome of turmeric, drying, pulverizing to 90 mesh, weighing 5.00g of dry powder, adding a mass fraction of 5.0% sodium dodecylsulfonate aqueous solution, the liquid-solid ratio is 12: 1. Ultrasonic extraction with a frequency of 30KHz and a power of 90W was used for 30 minutes, and the solid was separated to obtain an extract; sulfuric acid was added to the extract and heated for hydrolysis to obtain crude diosgenin, and the yield of the obtained diosgenin was determined to be 1.88%.

Embodiment 3

[0025] The method of this embodiment comprises the following steps: washing, drying, and pulverizing the fine yam rhizomes to 100 meshes, weighing 5.00 g of dry powder, adding a 7.0% aqueous solution of sodium dodecylbenzenesulfonate with a mass fraction of 7.0%, and the liquid-solid ratio 10:1, ultrasonic extraction with a frequency of 15KHz and a power of 120W for 10 minutes, the solid was separated to obtain an extract; after concentration, ethyl acetate was added to degrease, the concentrated solution was separated, and evaporated to dryness under reduced pressure to obtain 0.21 g of crude diosgenin. Crude diosgenin was hydrolyzed by adding sulfuric acid and heating to obtain crude diosgenin, which was recrystallized to obtain 0.091 g of high-purity diosgenin, and the yield of the obtained diosgenin was determined to be 1.82%.

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Abstract

The invention relates to a method for extracting dioscin, comprising the following steps: (1), plants containing dioscin are dried, pulverized and sieved to obtain dry powder; (2), a surfactant is dissolved in water to prepare a solvent; (3), the dry powder obtained in the step (1) and the solvent prepared in the step (2) are mixed at the ratio of 1:0.1-100:1, reinforced extraction is carried out by ultrasonic wave, a solid is separated out, and an extracting solution containing the dioscin is obtained; and (4), the extracting solution is processed to obtain rough dioscin or crude diosgenin. Compared with a traditional extracting method adopting an organic solvent, the method completely avoids using volatile organic solvents, such as methanol, ethanol, and the like, the optimal extracting time is shortened to less than 20 minutes of the method from more than ten hours of a traditional method, and the extracting efficiency is enhanced by 4-5 percent. In addition, an aqueous solution of the surfactant is adopted to carry out leaching; and compared with methanol and ethanol used in the prior art, the dioscin has greatly reduced cost and good safety and is especially suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a method for extracting diosgenin, in particular to a method for extracting dioscin from plants containing diosgenin by using ultrasonic-surfactant aqueous solution in combination. Background technique [0002] Diosgenin (diocsin) is ubiquitously present in various plants represented by the genus Dioscorea, and has biological activities such as anticancer, antibacterial, insecticidal, and anti-inflammatory. In addition, dioscin is also the basic raw material for the production of diosgenin (diosgenin) . Diosgenin, also known as saponin, has various pharmacological effects such as hemolysis, blood lipid lowering, antibacterial, and anti-inflammatory. It can be used as a basic pharmaceutical and chemical raw material for the synthesis of steroid hormone drugs and steroidal contraceptives. Market potential. At present, my country's annual output of diosgenin exceeds 2,000 tons, and China has become the world's largest producer o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00A61K36/894
Inventor 李谦刘绣华高向涛乔聪震张建新
Owner HENAN UNIVERSITY
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