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Liquid anti-rabies antibody formulations

A technology for rabies and rabies virus, applied in the direction of antiviral agents, antibodies, antibody medical components, etc., can solve the problems of not providing long-term stable pharmaceutical preparations of recombinant monoclonal antibodies, finding suitable excipients and optimal conditions, etc.

Inactive Publication Date: 2009-10-14
JANSSEN VACCINES & PREVENTION BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, finding suitable excipients and optimal conditions for formulating two different mAbs in a single formulation is more difficult
In particular, long-term stable pharmaceutical formulations containing two different recombinant monoclonal antibodies are not provided in the art

Method used

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  • Liquid anti-rabies antibody formulations
  • Liquid anti-rabies antibody formulations
  • Liquid anti-rabies antibody formulations

Examples

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Embodiment

[0042] The following examples are provided in order to illustrate the invention. The examples do not limit the scope of the invention in any way. Unless otherwise indicated, the present invention generally employs conventional chemistry, molecular biology, recombinant DNA techniques, immunology such as antibody techniques and standard polypeptide preparation techniques, such as Sambrook, Fritsch and Maniatis, Molecular Cloning: Cold Spring Harbor Laboratory Press (1989), Antibody Engineering Protocols (Methods in Molecular Biology), volume 51, Ed.: Paul S., Humana Press (1996), Antibody Engineering: APractical Approach (Practical Approach Series, 169), Eds.: McCafferty J. et al., Humana Press (1996); Antibodies: A Laboratory Manual, Harlow and Lane, Cold Spring Harbor Laboratory Press (1999) and techniques described in Current Protocols in Molecular Biology, Eds. Ausubel et al., John Wiley & Sons (1992).

[0043] The amino acid sequences of the CR57 and CR4098 antibodies are ...

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Abstract

The present invention provides pharmaceutical antibody formulations, in particular liquid pharmaceutical formulations comprising anti-rabies virus antibodies. The formulations can be used in the post exposure prophylaxis of rabies.

Description

field of invention [0001] The present invention relates to medicines. The invention particularly relates to stable formulations of specific anti-rabies antibodies. Background of the invention [0002] During the past decade, advances in the field of biotechnology have allowed the identification, development and production of a variety of antibodies for the diagnosis, prevention and treatment of many different diseases and conditions. An example of such an antibody is the anti-rabies virus antibody described in WO 2005 / 118644. An antibody cocktail of two such antibodies, CR57 and CR4098, is particularly advantageous for use in rabies post-exposure prophylaxis. In WO 2005 / 118644 these antibodies were prepared and used in PBS. [0003] As with any protein, the biological activity of an antibody, such as its binding affinity or neutralizing activity, depends on the conformational integrity of at least the core amino acid sequence remaining intact while protecting the protein'...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00C07K16/00
CPCC07K16/10A61K47/26A61K47/12A61K39/39591A61K9/0019A61P25/00A61P31/14A61K39/395C07K16/08
Inventor A·B·H·巴克W·E·马里森
Owner JANSSEN VACCINES & PREVENTION BV
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