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Use of pyrroloquinoline quinine in antiradiation

A technology of quinoline quinone and pyrrole, which is applied in the fields of biotechnology and medicine, and can solve problems such as the difficulty in accurate dosage and the difficulty in controlling the content and quality of anti-radiation functional factors.

Inactive Publication Date: 2009-08-19
SHANGHAIMED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are few foods and health products used for anti-radiation, including spirulina, ginkgo leaves, rhodiola rosea, etc., and their materials are mostly derived from natural animals and plants. It is difficult to control the content and quality of anti-radiation functional factors. The dosage is also difficult to be precise

Method used

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  • Use of pyrroloquinoline quinine in antiradiation
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  • Use of pyrroloquinoline quinine in antiradiation

Examples

Experimental program
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Effect test

preparation example Construction

[0065] Preparation and source of PQQ active substance

[0066] The pyrroloquinoline quinones used in the present invention may be natural or non-natural. Preferably, the pyrroloquinoline quinone is artificially synthesized or produced by fermentation (microbial fermentation, including gene recombination).

[0067] Internationally, pyrroloquinoline quinone is mainly synthesized by chemical methods, generally with tyrosine molecule as the carbon and nitrogen skeleton, through a dopaquinone (dopaquinone) intermediate, through a series of reactions to obtain pyrroloquinoline quinone[ Hendrickson and deVries, J. Org. Chem. 1982, 47: 1148-1150; Gainor and Weinreb, J. Org. Chem. 1982, 47: 2833-2837; Buchi et al., J. Am. Chem. Soc. 1985, 107 : 5555-5556; Gainor and Weinreb, 1982, J. Org. Chem. 46: 4317-4319]. However, these chemical synthesis methods have technical problems such as many steps, high cost, and difficult separation of reaction by-products.

[0068] Another method fo...

Embodiment 1

[0102] Example 1. Effect of pyrroloquinoline quinone on skin appearance in rats with radiation-induced skin injury

[0103] Materials and Methods

[0104] The animals used were 3-month-old SPF grade SD rats with a body weight of 250±5 g (provided by the Experimental Animal Center of Soochow University).

[0105] Use a linear accelerator (Philips SL18) to irradiate 4 Mev high-energy electron rays with a dose of 45Gy. The irradiated part is the buttocks of the rat, and the non-irradiated part is shielded with a lead plate. The irradiated area is 2cm×2cm, the dose rate is 200cGy / min, and the cages are separated after irradiation. feeding.

[0106] Use PQQ (pyrroloquinoline quinone, purchased from Shanghai Medical Life Science Research Center Co., Ltd.) to treat radiation skin damage, and divide the experimental animals into 4 groups randomly:

[0107] i. Normal group: 1 rat, without radiation treatment;

[0108] ii. Irradiated non-administered group (control group): 3 rats, ...

Embodiment 2

[0116] Example 2. HE staining of the effects of pyrroloquinoline quinone on the skin of rats with radiation-induced skin damage

[0117] Materials and Methods

[0118] With embodiment 1. The difference is that the skin samples from the irradiated field of rats in each group were collected every week, and the pathological HE staining was carried out according to the conventional method.

[0119] Results and discussion

[0120] The HE staining of the irradiated field skin tissue sections of rats in each group was as follows: figure 2 shown. The results show:

[0121] In the first week ( figure 2 A), the collagen fibers were broken, the epidermis had no necrosis, and no inflammatory reaction was seen; at the third week ( figure 2 E), the fracture of collagen fibers is more obvious, the upper layer of collagen fibers is necrotic, and the inflammatory reaction is more serious; at the fifth week ( figure 2 H), the collagen fibers are broken more thoroughly, there are ...

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Abstract

The invention relates to application of pyrroloquinoline quinone in radioresistance, in particular to application of an active ingredient of the pyrroloquinoline quinone in preparing a substance used for improving the radiation resistance of an object and lightening or eliminating the influence of the radiation on the object, wherein the active ingredient of the pyrroloquinoline quinone is selected from one or more of the pyrroloquinoline quinone, and bromatologically, hygienically or pharmaceutically acceptable salt and / or ester of the pyrroloquinoline quinone. The substance has remarkable effect on the radioresistance, and has the advantages of having low toxic side effect, supplementing ingredients needed by human bodies and the like.

Description

technical field [0001] The invention relates to the fields of biotechnology and medicine. In particular, the present invention relates to a substance for antiradiation, said composition comprising pyrroloquinoline quinone (or a salt or ester thereof) as an active ingredient. Background technique [0002] Radiation can be roughly divided into five types according to its source: (1) Natural radiation, mainly sunlight (especially ultraviolet radiation) and rays produced by natural substances such as minerals; (2) Electrical radiation, such as computers, mobile phones, microwave ovens, etc. (3) medical radiation, such as high-intensity radiation produced by X-rays, CT, nuclear magnetic resonance machines, etc.; (4) radiation from building materials, such as marble floors, tiles, etc.; and (5) nuclear radiation. [0003] In modern life, health problems caused by radiation are becoming more and more common and serious. A large number of scientific experiments at home and abroad ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61P17/16A23L1/30A23L33/10
Inventor 顾建新恽小婧陈晓宁吴怡虹吴士良吴祁生冷一欣
Owner SHANGHAIMED
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