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Anti-infective medicament composition and application

A composition and anti-infection technology, which are applied in the field of medicine and achieve the effects of good anti-multidrug resistance, high safety and broad antibacterial spectrum

Active Publication Date: 2009-08-12
广东恒健制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are no technical reports on the specific application of Phloroglucinol derivatives of Trichophyllum chinensis to the preparation of medicines.

Method used

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  • Anti-infective medicament composition and application
  • Anti-infective medicament composition and application
  • Anti-infective medicament composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the experiment of extract antifungal effect

[0031] 1.1 Materials and reagents

[0032] Species: Epidermophyton: Epidermophyton flocculum

[0033] Microsporum: Microsporum

[0034] Trichophyton: Trichophyton rubrum Trichophyton schlenii Trichophyton gypsumi

[0035] Trichophyton trichophyton

[0036] Medium: sandcastle agar medium

[0037] 1.2 Preparation of test solution

[0038] Extract preparation

[0039] Hair fern - ethanol extraction - ethanol extract, using the existing conventional technology.

[0040] 1.3 Experimental content

[0041] agar diffusion method

[0042] A small round filter paper piece (0.5 cm in diameter) was punched out with a hole punch according to the literature. The experimental tweezers, L-shaped glass rods, Petri dishes, droppers, small beakers and small round filter papers were dry-heat sterilized.

[0043] Using sandcastle agar base, in a sterile laboratory, pour about 25ml of medium into each petri dish ...

Embodiment 2

[0052] Example 2 Preparation of anti-infective pharmaceutical compositions 1-5 and comparison of anti-infective effects The extracts in the experimental compositions were prepared using conventional techniques:

[0053] Method 1: Hairy fern - ethanol extraction - petroleum ether or n-hexane extraction - column chromatography purification - six components in the extract are obtained.

[0054] Method 2: Trichophyllum - extraction with petroleum ether or n-hexane - column chromatography purification - to obtain six components in the extract.

[0055] The positive control solution uses the methanol extraction solution of dacryline.

[0056] Mix the six ingredients according to the following proportions to obtain a mixed extract solution:

[0057] Extract mixed solution 1:

[0058] By weight, with dryofragin (Dryofragin) 20%, aspidin AB (AspidinAB) 30%, aspidin PB (Aspidin PB) 10%, aspidin BB (Aspidin BB) 5%, aspidin The total weight of the mixed extract of Aspidinol 15% and Alb...

Embodiment 3

[0075] Example 3 Preparation of an anti-infective ointment

[0076] (1) Prepare the extract mixed solution, add the extract mixed solution to water and stir to obtain the water phase;

[0077] The oil phase is prepared by heating and melting the excipients;

[0078] (2) Add the oil phase to the water phase to prepare ointment.

[0079] The specific operation process is as follows: Take 0.2g of sodium lauryl sulfate and 0.5mL of glycerin in a small beaker, heat it in a water bath at 76°C until it melts; take 1.8g of stearyl alcohol, 2g of white petrolatum, 1.2g of liquid paraffin, and Platinum ethyl fat 0.02g, heated at 76°C in a water bath until completely melted, took 6mL of the mixed solution of the extract with a pipette, added it to water, stirred it with a glass rod, took it out, stirred it quickly with an automatic stirrer, and at the same time Slowly add the oil phase to it, gradually reduce the stirring speed as the temperature drops, add 1-2 drops of liquid paraffin d...

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Abstract

The invention discloses an anti-infective drug combination and an application thereof. The anti-infective drug combination comprises a dryopteris fragrans extract with the weight percentage being 1% to 99% of the drug combination, and pharmaceutically conventional auxiliary materials. The dryopteris fragrans extract comprises the following components: dryopteris fragrans essence, aspidin AB, aspidin PB, aspidin BB, aspidinol and albicanol. The anti-infective drug combination is applicable in the preparation of drugs for curing bacterial, fungal or viral infection diseases; and the anti-infective drug combination has the advantages that the anti-bacterial spectrum is wide, the anti-multidrug resistance is good and the safety is high because the anti-infective drug combination is derived from the natural plant resources.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anti-infection pharmaceutical composition and its application. Background technique [0002] Dryopteris fragrans L. is a plant of the genus Dryopteridaceae, which mainly grows in Wudalianchi, Heilongjiang Province and North China. The drug has not yet been included in the Pharmacopoeia, and its research at home and abroad only involves theoretical research on pharmacognosy, chemistry and pharmacodynamics. [0003] The applicant has devoted himself to the related research of D. chrysalis for a long time, and obtained research results. In "Chinese Herbal Medicine", Volume 36, No. 5, in May 2005, "Inhibitory Effects of Trichophyllum on Fungi" was published, explaining the antifungal effect of Trichofernium extracts; in April 2006, No. 22 Volume 2 of "Chinese Herbal Medicine" published the hair fern CO 2 GC-MS analysis of supercritical extracts", which discloses 15...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K31/12A61K31/045A61P31/00A61K9/06
Inventor 沈志滨
Owner 广东恒健制药有限公司
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