Method for extracting poppy capsule total alkaloid from poppy capsule extract liquid

Abstract

The invention discloses a method for separating total alkaloid from traditional Chinese medicine, in particular a method for separating total alkaloid from an extracting solution of the traditional Chinese medicine, namely poppy capsule, and belongs to the field of traditional Chinese medicines. The method comprises the following technical proposal: taking the extracting solution of the poppy capsule; adjusting the pH value of the extracting solution to between 1 and 7; filtering the extracting solution; taking and adding the filtrate to a cation exchange resin column; rinsing the filtrate and removing the impurities; eluting the filtrate with 0.5 to 15 percent acid liquor; checking eluent until no alkaloid exists; collecting the eluent; adding alkali to the eluent for neutralization; performing desalting treatment on the mixed solution; and performing concentrated drying to obtain the poppy capsule total alkaloid. The method overcomes the defects of low extracting rate, large using level of organic solvent, complicated process, inability of large-scale production, and the like in the prior art and can efficiently separate high purity of the poppy capsule total alkaloid from the extracting solution of the poppy capsule.

Description

technical field [0001] The invention relates to a method for extracting and separating active ingredients of traditional Chinese medicines, in particular to a method for extracting and separating total alkaloids of poppy shells from traditional Chinese medicine poppy shell extracts, belonging to the field of traditional Chinese medicines. Background technique [0002] Alkaloids are a large class of basic nitrogen-containing compounds that widely exist in nature, are active ingredients of many Chinese herbal medicines, and are an important class of substances in nature. Poppy husk, recorded in the 2005 edition of the Chinese Pharmacopoeia on page 256, is the dried and mature husk of the poppy plant Papaver somniferum L., also known as poppy husk, poppy husk, etc., is a commonly used folk Chinese herbal medicine It has the effects of astringing the lungs, astringent intestines, and relieving pain. Studies have shown that the total alkaloids of poppy shell are its main effecti...

AI Technical Summary

Problems solved by technology

Although this method can improve the purity of alkaloids and has made some progress, there are still serious defects: the test found that the efficiency of alkalizing the resin with ammonia water was low, resulting in a low yield; free poppy shell organisms under alkaline conditions Alkali needs to have good solubility in organic solvents, but the use of organic solvents will bring residues of resin monomer components such as styrene, divinylbenzene, and organic solvents into the eluent, which will affect the safety of the preparation; the test process In the process, the resin needs to be poured out and dried, then alkalized with ammonia water, and refluxed with a variety of organic solvents to extract. In the step of solvent treatment, the organic solvent must be recovered in the later stage, which increases the process steps and increases the production cost