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Medicament composition of amlodipine and simvastatin as well as preparation method and application thereof

A technology of amlodipine and simvastatin, applied in the field of medicine, can solve the problems of enhancing the blood pressure lowering effect of amlodipine, taking it in the evening, and taking the antihypertensive drug in the morning, etc., so as to improve the safety and tolerance, reduce the Dosage, enhance blood pressure lowering effect

Inactive Publication Date: 2009-07-22
NAT INST OF PHARMA R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in the literature that the combined clinical application of simvastatin and amlodipine (lipid-lowering drugs taken in the evening and antihypertensive drugs in the morning) can significantly enhance the blood pressure-lowering effect of amlodipine, but the effect of simvastatin on blood lipid-lowering did not significantly affect

Method used

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  • Medicament composition of amlodipine and simvastatin as well as preparation method and application thereof
  • Medicament composition of amlodipine and simvastatin as well as preparation method and application thereof
  • Medicament composition of amlodipine and simvastatin as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Formulation Example 1: Amlodipine and Simvastat Tablets

[0038] component Dosage (g) Simvastatin 15 Amlodipine 5 low substituted hydroxypropyl cellulose 30 Calcium hydrogen phosphate 125 Butylated Hydroxyanisole (BHA) 0.06 lactose 217 talcum powder 3 Magnesium stearate 1.5 Polyvinylpyrrolidone 1.5 95% ethanol Moderate co-produced 1000 capsules

[0039] Preparation:

[0040] Pass amlodipine, simvastatin, lactose, low-substituted hydroxypropyl cellulose, calcium hydrogen phosphate, etc. through an 80-mesh sieve respectively, after mixing evenly, add an ethanol solution of butylated hydroxyanisole, granulate with a 20-mesh sieve, and 40 18 mesh sieve to granulate, add magnesium stearate, and talc, mix evenly, and then press into tablets.

[0041] Formulation Example 2 Amlodipine and simvastatin tablets.

[0042] formula:

[0043] component Dosage (g) Simvastatin 10 ...

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Abstract

The invention discloses a pharmaceutical composition of amlodipine and simvastatin, which belongs to the technical field of medicine. The pharmaceutical composition is prepared by combining the amlodipine and the simvastatin according to the weight ratio of 1: 1.5-16, and pharmaceutical excipients can also be added to prepare a steady preparation form. A compound medicine of the invention can be taken at any time (before and after dinner), improve the inconvenience that a hypotensor and a lipid-lowering medicine need to be taken respectively, and increase the compliance of patients. On the other hand, the pharmaceutical composition can remarkably strengthen the effect of blood pressure reduction when not decreasing the effect of blood lipid reduction, and can reduce the dosage of drug use; and a complex prescription formed by the amlodipine and the simvastatin can remarkably reduce the toxic effect when the two medicines are used singly, and improves the safety and tolerance. The pharmaceutical composition can be used as a novel medicine for treating mixed hypertension and hyperlipidemia.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to a compounded medicinal composition with antihypertensive and lipid-lowering effects, a preparation method thereof, and an application of the medicinal composition in the preparation of a medicine for treating mixed hypertension and hyperlipidemia. Background technique: [0002] Statistics from authoritative health institutions show that the morbidity and mortality of cardiovascular, cerebrovascular, renal and vascular diseases in my country are increasing year by year. Hypertension and hyperlipidemia are two important risk factors for atherosclerosis, angina pectoris, myocardial infarction, cerebral infarction, and kidney damage. Therefore, it is very important to pay attention to hypertension, hyperlipidemia, and actively control the occurrence of cardiovascular and cerebrovascular diseases. [0003] Amlodipine (A) is a dihydropyridine calcium blocker, a new generation of calci...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/366A61P9/12A61P3/06
Inventor 孙从新郑少辉郑礼王秋陈牛艳刘芳雷李蕾刘梦莹祝浩淼
Owner NAT INST OF PHARMA R & D CO LTD
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