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White peony root dispensing granule as well as preparation method and quality control method thereof

A technology of formula granules and white peony, applied in the field of white peony formula granules and its preparation, can solve problems such as difficulties in map analysis

Active Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • White peony root dispensing granule as well as preparation method and quality control method thereof
  • White peony root dispensing granule as well as preparation method and quality control method thereof
  • White peony root dispensing granule as well as preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: Paeoniae Alba Formula Granules

[0037] Take 100kg of Radix Paeoniae Alba, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.05- 1.10; the concentrated solution is preheated at 45°C, the inlet air temperature is 180°C, the material pump speed is 550 rpm, the outlet air temperature is 80°C, and the air supply temperature is 45°C, and spray-dried to obtain the spray-dried powder of Radix Paeoniae Alba; Add the auxiliary material dextrin of its own weight portion 0-5% in the spray drying powder of peony; Dry granulation under the condition of 120V to obtain 20-60 mesh white peony formula granules, each gram of white peony formula granules is equivalent to 20 grams of crude drug.

Embodiment 2

[0038] Embodiment 2: Paeoniae Alba Formula Granules

[0039] Take 100kg of Radix Paeoniae Alba, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.00- 1.05; the concentrated solution is preheated at 50°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air delivery temperature is 50°C, and it is spray-dried to obtain Radix Paeoniae Alba spray-dried powder; Add the auxiliary material dextrin of 5-15% of its own weight in the spray-dried peony powder; under the conditions that the pressure of the main pressure roller is 6MPa, the pressure of the side pressure roller is 0.4MPa, the rotational speed of the main shaft is 450 rpm, and the feeding voltage is 110V Dry granulation to obtain 20-60 mesh...

Embodiment 3

[0041] Embodiment 3: Paeoniae Alba Formula Granules

[0042] Take 100kg of Radix Paeoniae Alba, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.10- 1.15; the concentrated solution is preheated at 45°C, the air inlet temperature is 170°C, the material pump speed is 600 rpm, the air outlet temperature is 75°C, and the air supply temperature is 50°C, and the spray drying is obtained to obtain the spray-dried powder of Radix Paeoniae Alba; Add 15-25% of its own weight of lactose in the spray-dried peony powder; the pressure of the main roller is 4MPa, the pressure of the side roller is 0.4MPa, the spindle speed is 500 rpm, and the feeding voltage is 130V. granules, to obtain 20-60 mesh white peony formula granules, each gram of white peony formula granul...

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Abstract

The invention discloses a radix paeoniae alba formula particle and preparation and quality control methods thereof. The formula particle is made from radix paeoniae alba decoction pieces used as raw materials, and the decoction pieces are processed by the technological processes of two times of water extraction, depressurization, concentration, spraying, drying, and the like to gain the radix paeoniae alba formula particle; and one gram of radix paeoniae alba formula particle is equivalent to 10 to 20 gram of crude medicines, and the quality of the radix paeoniae alba decoction pieces and that of the radix paeoniae alba formula particle are respectively discriminated by the infrared fingerprint spectra. The radix paeoniae alba formula particle of the invention has the advantages of integrated and advanced production process, high special and controllable quality control standard and advanced and realizable process, and a test method for the quality standard is scientific, advanced, fast and highly practical. as Proven by experiments, the ingredient of a herbal decoction prepared by the radix paeoniae alba formula particle of the invention is equivalent to the ingredient of a radix paeoniae alba contained classic formula co-decoction, the full ingredient formula particle process is achieved, and the process of the invention is proven to be reasonable; and the invention applies the infrared spectra technology to the quality control of the traditional Chinese medicine, thereby fast solving the principle problem of traditional Chinese medicine discrimination in the macroscopical quality control of the traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule and a preparation method and a quality control method thereof, in particular to a white peony formula granule and a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with wate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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