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Composition for promoting the production of equol

A technology of equol and composition, which is applied in the field of equol production-promoting composition, can solve the problems of low ability to produce equol, achieve the effect of low addition amount, improve eggshell strength, and prevent osteoporosis

Inactive Publication Date: 2009-07-01
UNITIKA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has actually been reported that approximately 60-70% of Europeans and Americans have a low capacity to produce equol

Method used

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  • Composition for promoting the production of equol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 [Determination of the equol production-promoting effect of calcium lactobionate in rats]

[0045] 1. Sample

[0046] Calcium lactobionate (manufactured by Sigma Aldrich) was mixed with mouse feed powder (CRF-1, manufactured by Oriental Yeast Co., Ltd.) to a concentration of 0% by weight, 0.5% by weight or 3.0% by weight. In addition, feed powder mixed with 1.5% by weight of digructose dianhydride III (DFA-III) (manufactured by Wako Pure Chemical Industries, Ltd.) and feed powder mixed with 1.5% by weight of fructo-oligosaccharide (FOS) (manufactured by Wako Pure Chemical Industries, Ltd.) Feed powder was used as a reference control.

[0047] 2. Experimental Animals and Feeding

[0048] Five-week-old SD mice (from Clea Japan, Inc.) were habituated and fed for one week, with 3 animals in each group, allowing them to freely ingest feed powder CRF-1 and water. The time when the habituation feeding was completed was regarded as week 0. Starting from the 0th wee...

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Abstract

The object is to provide a composition which can significantly promote the production of an equol. When added to a pharmaceutical agent or a beverage / food, the composition can exerts an effect of preventing a vascular disease because of its cholesterol level-lowering effect, an effect of preventing breast cancer or prostate cancer, and an effect of preventing and / or treating osteoporosis. When added to an animal feedstuff or a pet food, the composition can exert an effect of increasing the bone density to thereby prevent the leg weakness in pigs, strengthen an egg shell in egg-laying chickens, and prevent osteoporosis in dogs or the like.Thus, disclosed are: a composition comprising lactobionic acid, a salt thereof or lactobionolactone as an active ingredient; and a beverage / food, animal feedstuff, pet food or a pharmaceutical agent comprising the composition and having an effect of preventing or treating osteoporosis, an effect of increasing the bone density, an effect of preventing breast / prostate cancer, and an effect of lowering the cholesterol level.

Description

technical field [0001] The present invention relates to an equol production-promoting composition used in food or drink, feed, medicine, etc., from which effects such as promoting equol production in the intestine and improving bone density can be obtained after ingestion. Background of the invention [0002] Osteoporosis is becoming a serious problem with an aging society, which reduces bone density and leads to easy fractures as we age. Osteoporosis has been found to lead to fractures of the lumbar spine or femur / tibia due to a decrease in bone mineral content and thus be a cause of bed rest. In particular, women are prone to osteoporosis due to the rapid decrease in bone mineral content due to decreased estrogen secretion at the onset of menopause. As for the treatment of osteoporosis, it is considered very important to prevent osteoporosis from a young age or to prevent a rapid decline in bone mineral content after menopause, since once the bone mineral content is reduc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/04A61K31/7032A61P3/06A61P19/00A61P19/10A61P35/00A61P43/00
CPCA23L1/30C07H3/04A23K1/1609A61K31/7016A61K31/7012A61K31/7032A23K20/105A23L33/10A61P19/00A61P19/10A61P35/00A61P3/06A61P43/00A61P9/00
Inventor 大江健一木村隆
Owner UNITIKA LTD
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