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Ceftibuten sustained-release capsule

A technology of sustained-release capsules and ceftibuten, which is applied in the new field of medicine, can solve problems such as inconvenience, and achieve the effect of high quality, simple method and good stability

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the third-generation varieties need to be administered by injection, which is very inconvenient

Method used

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  • Ceftibuten sustained-release capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: specification 1000 grains

[0030] prescription:

[0031] Ceftibuten 200g

[0032] Microcrystalline Cellulose 40g

[0033] Ethyl cellulose 80g

[0034] Dextrin 60g

[0035] Silica 5g

[0036] Preparation method:

[0037] Dissolve the prescribed amount of ethyl cellulose with ethanol and set it aside for later use. Pass the prescribed amount of ceftibuten through a 100-mesh sieve and mix it with the prescribed amount of microcrystalline cellulose and dextrin. Add the ethyl cellulose solution in portions. 18-mesh granulation, adding appropriate amount of silicon dioxide, 20-mesh granulation, mixing evenly, measuring the content of intermediates, filling capsules after passing the test, and inspecting and packaging the finished product.

Embodiment 2

[0038] Embodiment 2: specification 10000 grains

[0039] prescription:

[0040] Ceftibuten 2000g

[0041] Microcrystalline Cellulose 400g

[0042] Ethylcellulose 450g

[0043] Dextrin 600g

[0044] Silica 50g

[0045] Preparation method:

[0046] Dissolve the prescribed amount of ethyl cellulose with ethanol and set it aside for later use. Pass the prescribed amount of ceftibuten through a 100-mesh sieve and mix it with the prescribed amount of microcrystalline cellulose and dextrin. Add the ethyl cellulose solution in portions. 18-mesh granulation, adding appropriate amount of silicon dioxide, 20-mesh granulation, mixing evenly, measuring the content of intermediates, filling capsules after passing the test, and inspecting and packaging the finished product.

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Abstract

The invention belongs to the novel technical field of medicaments, and relates to a novel dosage form of ceftibuten for treating upper respiratory tract infections, such as pharyngitis, tonsillitis, scarlatina, parasinusitis and tympanitis; lower respiratory tract infections, such as acute bronchitis, acute onset of chronic bronchitis, pneumonia; urinary tract infection; enteritis and gastroenteritis. The novel dosage form is characterized in that the product is a sustained release capsule which slowly releases drugs in the water or prescribed release media at non-constant speed. Through the slow release, the drugs reach a stable blood concentration level in vivo, and the undesirable reactions and drug-resistant strains thereof are reduced.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of ceftibuten, which is used for treating upper respiratory tract infections such as pharyngitis, tonsillitis, scarlet fever, paranasal sinusitis and otitis media; lower respiratory tract infections such as acute bronchitis and acute chronic bronchitis seizures, pneumonia; urinary tract infection; enteritis and gastroenteritis. Specifically, it relates to a preparation method and application of ceftibuten sustained-release capsules. Background technique [0002] Cephalosporin antibiotics have the characteristics of broad antibacterial spectrum, strong antibacterial activity, high curative effect, and low toxicity, and have been widely used clinically. By 1998, 56 varieties including the first generation to the fourth generation were on the market in the world. Since the first-generation cephalosporin cephalothin was successfully developed in China in the 19...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/546A61K47/38A61P31/04
Inventor 王翰斌闫艳立吴广俣
Owner BEIJING HOPE HUGE PHARM SCI
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