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Hemostasia material based on chitosan, collagen and sodium cellulose glycolate and preparation method and use thereof

A technology of sodium carboxymethyl cellulose and collagen, applied in medical science, absorbent pads, bandages, etc., can solve problems such as insufficient viscosity, inconvenient clinical use, and non-biocompatibility of wounds, so as to prevent postoperative Adhesion, wound healing effect

Inactive Publication Date: 2009-06-10
张博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems in the prior art that the hemostatic material has poor adsorption function, insufficient viscosity, no biocompatibility with the wound, no antibacterial function and inconvenient clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0011] Configure glacial acetic acid solution (concentration is 0.1%~5%), add disodium hydrogen phosphate (concentration is 0.1%~5%), sodium hydrogen phosphate (concentration is 0.1%~5%), chitosan (weight 1~4%) gram); configure glacial acetic acid solution (concentration is 0.1%~5%), add simethicone oil (concentration is 0.1%~5%), sodium carboxymethyl cellulose (weight 3~4 grams), raise the temperature to 10-65°C, stir evenly; configure glacial acetic acid solution (concentration is 0.1% to 5%), add disodium hydrogen phosphate (concentration is 0.1% to 5%), sodium hydrogen phosphate (concentration is 0.1% to 5%), Collagen (6-12 grams in weight). Under the condition of stirring or ultrasonic vibration, add the glacial acetic acid solution of chitosan to the glacial acetic acid solution of collagen, and stir quickly; then mix the above solution with the CMC solution under stirring, and raise the temperature to 40°C for mixing uniform; finally, freeze-dry quickly in a freeze-dry...

Embodiment approach 2

[0012] Embodiment two: the difference between this scheme and scheme one is that chitosan: collagen: the weight ratio of sodium carboxymethyl cellulose is (1~3): (9~12): (1~3), other processes It is the same as method and scheme one.

Embodiment approach 3

[0013] Embodiment three: the difference between this scheme and the above scheme is that chitosan: collagen: the weight ratio of sodium carboxymethyl cellulose is (3~4): (6~9): (3~24), other processes It is the same as the method and the above scheme.

[0014] Using the production process described in the invention, the unique hemostatic sponge of chitosan, collagen and CMC can be formed. This is conducive to the gradual and constant release of the drug and exert a specific effect. After the finished product is in contact with the wound, it will quickly exert its hemostatic effect. The collagen in it will be released, seal the wound, stop bleeding and promote wound healing. At the same time, chitosan will play the role of antibacterial, preventing wound adhesion and hemostasis in the later stage.

[0015] Chitosan collagen has good viscosity and strong adsorption when it meets blood, and has good antibacterial function and good biocompatibility. Moreover, this product has be...

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Abstract

The invention provides a hemostatic material based on chitosan, collagen and sodium carboxymethyl cellulose which includes chitosan, collagen and sodium carboxymethyl cellulose for forming hemostatic sponge of chitosan, collagen and sodium carboxymethyl cellulose.

Description

technical field [0001] The invention relates to a medical material and a preparation method thereof, in particular to a hemostatic material based on chitosan, collagen and sodium carboxymethyl cellulose and a preparation method thereof. Background technique [0002] Collagen is the main component of the extracellular matrix. A large number of research work on collagen-modified biomaterials at home and abroad mainly focuses on the development of natural dermis substitutes and artificial dermis. The main representative products include artificial skin, hemostatic sponge and medical Collagen membrane. The point of interest of the inventor's research lies in hemostasis. For the hemostatic sponge, CN1385143A, CN1433814A, and CN1569244A disclose biological collagen hemostatic cotton and its preparation method, but the toughness of the pure collagen hemostatic sponge is relatively poor and has no antibacterial effect; CN1387922A discloses two kinds of cotton containing collagen an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44
Inventor 张博
Owner 张博
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