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Dermal filler composition

A technology of dermal fillers and compositions, which is applied in the field of dermal filler compositions, can solve the problems of high cost and difficult dermal filler treatment, etc., and achieve the effect of promoting penile enlargement, not easy to decompose or absorb, and long-term stable volume expansion Effect

Active Publication Date: 2011-06-15
曹康善 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This makes dermal fillers expensive, difficult to accept, and drives most patients to surgery, such as autologous skin fat grafts or stored dermis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] Polymethyl methacrylate (PMMA) is the main ingredient in the dermal filler composition of the present invention, and it is a microsphere with a diameter of 30-120 μm. This size is large enough not to be phagocytized by macrophages and less likely to penetrate into the surrounding area where PMMA-induced fibrosis would occur. When PMMA is injected into the skin, it will directly increase the volume without being absorbed by the body, and remain at the application site for a long time or permanently, and stimulate fibroblasts to produce collagen. The resulting collagen encapsulates the PMMA, and the encapsulated PMMA microspheres fill in wrinkles or other sunken areas.

[0019] Another ingredient of the dermal filler composition of the present invention is cross-linked dextran, examples of which include DEAE Sephadex (Pharmacia Fine Chemicals). It is a microsphere with a diameter of 30-120 μm. When it is injected into the skin, the cross-linked dextran increases the vol...

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PUM

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Abstract

Disclosed herein is a dermal filler composition. The composition includes polymethylmethacrylate (PMMA), cross-linked dextran, hydroxypropyl methylcellulose (HPMC), and physiological saline or distilled water. The composition rapidly restores volume at application sites by injection, does not require pre-testing, such as allergic skin testing, because it does not cause severe allergic reactions, is cheap, and is not easily degraded or absorbed in the body, thus ensuring a long-lasting volume augmentation effect. Due to the characteristics described above, the composition facilitates volume correction requiring a large amount (20 cc or greater) of dermal filler such as in augmentation phalloplasty.

Description

technical field [0001] The present invention relates to a dermal filler composition, more specifically, to a composition containing polymethylmethacrylate (PMMA), cross-linked dextran, hydroxypropylmethylcellulose (HPMC) and physiological saline or distilled water Dermal filler composition. Background technique [0002] The soft tissues of the human body maintain their structure thanks to proteins such as collagen and elastin and an extracellular matrix containing mucopolysaccharides. However, soft tissue defects caused by trauma, congenital abnormalities, or diseases can be restored or corrected by injecting biological tissue, transplanting autologous tissue, or injecting synthetic polymers to expand the soft tissue at the site of the soft tissue defect. [0003] Materials that resemble skin tissue, called dermal fillers, are often used to remove wrinkles or correct contours. This material is injected into specific defects in the skin to augment the soft tissue. This typ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/10
CPCA61F2/26A61L27/50A61L27/26C08L5/02C08L33/12A61F2/105
Inventor 曹康善
Owner 曹康善
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