Injection for treating milk cattle mastitis and preparation method thereof

Abstract

The invention discloses an injection for treating bovine mastitis and a preparation method thereof. The injection is characterized in that each 100 milliliters of the injection consists of 25 to 70 grams of coptis root crude medicines, 25 to 70 grams of dandelion crude medicines, extract which is subjected to aqueous extraction and alcohol precipitation by 25 to 70 milliliters of pig bile, and 1.5 to 12 grams of lincomycin. The preparation method is as follows: the injection is refined by aqueous extraction and alcohol precipitation for multiple times. The injection has strong functions of bacteriostasis and sterilization on Staphylococcus aureus, streptococcus and Escherichia coli, simultaneously has the functions of nonspecific anti-inflammation and immunoregulation, and can obviously inhibit proliferation of the Staphylococcus aureus in mammary glands, reduce PMN infiltration, and reduce the TNF-alpha level and the TNF-gamma level of the mammary tissue and the TNF-gamma level of blood serum, so as to relieve pathological injury of inflammatory media on the mammary glands. The injection is used for treating bovine mastitis, can be subjected to basin irrigation and also can be subjected to intramuscular injection, is convenient to use, has high treatment effect and small side effect, and is a novel generation of currently advanced mastitis-resistant medicine which not only has strong antibacterial action but also has the function of the immunoloregulation.

Description

Technical field: [0001] The invention relates to a novel veterinary medicine for treating cow mastitis. Specifically, it is an injection for treating cow mastitis. Background technique: [0002] Cow mastitis is an inflammatory change of the mammary gland accompanied by physical, chemical and microbiological changes, which is characterized by an increase in somatic cells in the milk, especially leukocytes, and pathological changes in the mammary gland tissue; it affects the development of the dairy industry in the world and gives dairy products A common frequently-occurring disease that causes huge losses in production. According to the survey, the incidence rate of clinical mastitis dairy cows in my country is 33.41%; the positive detection rate of recessive mastitis dairy cows is 73.91%. In my country, dairy cows eliminated due to clinical mastitis account for about 9% to 11% of the total eliminated cattle, which has caused great economic losses. At present, there are ab...

AI Technical Summary

Problems solved by technology

First, the emergence of drug-resistant strains and changes in pathogenic flora reduce the efficacy of antibiotics. The latest research has found that Staphylococcus aureus can persist in macrophages and mammary epithelial cells for a long time, while traditional antibiotics usually cannot penetrate into cells or enter cells. The concentration is too low to achieve therapeutic effect

Another disadvantage of antibiotic therapy is the problem of antibiotic residues in milk, which can induce hypersensitivity reactions in the human body and pose a great threat to human health

However, pure traditional Chinese medicine preparations have no residue and little toxic and side effects, but their antibacterial efficacy is far inferior to that of antibiotics.