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Total alkaloid extract, and extraction method thereof and use in preparing medicament for treating cough

Active Publication Date: 2011-05-11
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the specific embodiment wherein has only carried out relevant research to leaf hundred plants, and has not carried out relevant research to other plants of the genus Phalaenopsis

Method used

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  • Total alkaloid extract, and extraction method thereof and use in preparing medicament for treating cough
  • Total alkaloid extract, and extraction method thereof and use in preparing medicament for treating cough
  • Total alkaloid extract, and extraction method thereof and use in preparing medicament for treating cough

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Experimental program
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specific Embodiment

[0037] The dry rhizome of Stemona sessilifolia used in the experiment was collected from Hainan Province, China, and was identified as Stemona sessilifolia by Associate Professor Shen Jingui from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The evidence sample of this plant material is preserved in the Shanghai Institute of Materia Medica, Chinese Academy of Sciences; the baptine reference substance used in the experiment was isolated by the inventor of the present application.

[0038] In this experiment, male adult Dunkin-Hartley guinea pigs (body weight 300-500 g) were used, provided by the Experimental Animal Center of the Chinese University of Hong Kong. The guinea pigs were placed in a laboratory (temperature 21±1° C.; humidity 60%), with a natural day / night cycle and given standard food and water.

[0039] In this article, unless otherwise specified, the ratios of solvents involved are volume ratios.

Embodiment 1

[0041] Extraction of the total extract of Licorice chinensis

[0042] The dried rhizome (10kg) of Stemona sessilifolia was chopped, soaked three times in 95% ethanol at room temperature, each dosage was 10L, and the time was 72 hours. The three extracts were combined and concentrated under reduced pressure to obtain a slurry liquid, which was the total extract of C. erectus ( 350g).

Embodiment 2

[0044] Extraction of effective total alkaloids extract

[0045] Add dilute hydrochloric acid solution (4%) to the slurry obtained in Example 1 for acidification, and adjust the final pH to 1 to 2, filter out the insoluble matter under reduced pressure, and extract the obtained filtrate three times with diethyl ether, each time with diethyl ether 200ml, the aqueous phase after extraction is acid water. Acidic water was basified with ammonia water to pH 9-10, extracted repeatedly with chloroform, each time with 200ml of chloroform, until the water phase had no alkaloid reaction, combined the organic phases, concentrated chloroform under reduced pressure to obtain the effective total alkaloid extract of C. chinensis ( 42g).

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Abstract

The invention belongs to the field of pharmaceutical chemistry and discloses an effective total alkaloid extract of stemonaceae stemona sessilifolia, an extraction method thereof and application in preparing a medicine for treating cough. The effective total alkaloid extract of stemonaceae stemona sessilifolia has the activity of relieving and / or inhibiting cough.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and more specifically relates to an effective total alkaloid extract extracted from erect plants of the genus Libuca genus Libuca, an extraction method thereof, and an application in preparation of medicine for treating cough. Background technique [0002] A cough is a sudden burst of exhalation to clear the airways of material (phlegm). [0003] Cough itself is a protective reflex, which can clear the viscous secretions in the pharynx and the entire respiratory tract, inhaled harmful substances or foreign objects, so coughing is an important defense mechanism of the human body, and it is very harmful if it weakens or disappears. It can even be fatal. But the impact of cough on people's health is dialectical. Long-term frequent cough can affect the patient's breathing, heart and daily life, work, so it is harmful, and it is also the reason why people often seek medical advice. According to a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/55A61K36/904A61P11/14
Inventor 叶阳林鸽林理根约翰·安东尼·鲁德李希强唐春萍柯昌强
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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