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Method for preparing salts of Corydalis ambigua total alkaloid and use thereof as medicament for treating cardiovascular disease

A technology of total alkaloids and salt-forming reaction, which is applied in the direction of cardiovascular system diseases, drug combinations, medical preparations containing active ingredients, etc., can solve the problem of low bioavailability, poor effect of cardiovascular diseases, water solubility of total alkaloids of Corydalis No problem, etc., to achieve high bioavailability and good water solubility

Inactive Publication Date: 2009-04-15
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] In order to solve the problem of poor water solubility and low bioavailability of total alkaloids of Corydalis, the present invention provides a preparation method and application of total alkaloids of Corydalis

Method used

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specific Embodiment approach 1

[0008] Embodiment 1: The preparation method of the total alkaloid salt of Corydalis Corydalis in this embodiment is as follows: 1. Pulverize the Corydalis Corydalis medicinal material into a 20-50 mesh coarse powder, extract the Corydal Corydalis Corydalis medicinal material coarse powder with solvent extraction, and then filter the extract ; 2. Pass the extract through a strong-acid cation exchange resin column at a flow rate of 2 to 15ml / min for exchange and adsorption; 3. Clean the strong-acid cation-exchange resin after exchange and adsorption with distilled water until the cleaning solution is colorless, and use a strong-acid cation exchange resin Soak strong-acid cation-exchange resin in ammonia water with 1 / 16-1 / 4 of the weight of the exchange resin for 6-24 hours, then use organic solvent to reflux or Soxhlet-extract the alkalized strong-acid cation-exchange resin, the extraction time is 2 After ~8 hours, filter the extract and reclaim the organic solvent to obtain the ...

specific Embodiment approach 2

[0010] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in step 1, Corydalis Corydalis is crushed into 25-35 mesh coarse powder. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0011] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in step 1, Corydalis Corydalis is crushed into 20-mesh coarse powder. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The invention relates to a preparation method for traditional Chinese medicine alkaloid salt and application thereof, in particular to a preparation method for fumitory total alkaloids salt and application of the total alkaloids salt as a medicament for treating cardiovascular diseases. The method solves the problem of poor effect of treating the cardiovascular diseases due to poor water solubility and low bioavailability of the fumitory total alkaloids salt. The preparation method for the fumitory total alkaloids salt comprises the following steps: extracting and purifying fumitory coarse powder to obtain the fumitory total alkaloids, and then carrying out salt-forming reaction between the fumitory total alkaloids and acid to obtain the fumitory total alkaloids salt. The extraction ratio of the fumitory total alkaloids is more than 0.5 percent, and the purity of the obtained fumitory total alkaloids salt is more than 50 percent. The fumitory total alkaloids salt has the advantages that the fumitory total alkaloids salt has good water solubility, has a solubleness more than 60 percent, has high bioavailability, and is used as an effective component for treating the cardiovascular diseases, such as coronary heart disease, angina pectoris, arrhythmia and premature beat.

Description

technical field [0001] The invention relates to the preparation and application of a traditional Chinese medicine alkaloid salt. Background technique [0002] Worldwide, coronary heart disease has become one of the most serious diseases threatening human health, and its morbidity and mortality are on the rise. The average prevalence of coronary heart disease in my country is 6.49%, and it increases with age. Therefore, coronary heart disease is the most common cardiovascular disease among middle-aged and elderly people. Studies have shown that the main active ingredients of Corydalis are total alkaloids, including d-corydalline, d-corydalis monophenolic alkaloids, dl-tetrahydropalmatine, l-tetrahydrocorydine, and dehydrocorydalis Alkaline, l-coptisine, protropine, l-tetrahydro-African antihexamine, etc. The total alkaloids of Corydalis can expand coronary blood vessels, improve coronary blood flow, and protect myocardial ischemia and necrosis. In clinical practice, the to...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P9/06A61P9/10
Inventor 田明孙世晓周忠光来杰
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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