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Nanometer lipid sun-prevention microparticle suspending liquid and preparation method thereof

A nano-lipid, suspension technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of coating sunscreens that have not yet been disclosed, and coating cosmetics with few active components, and avoid high pressure. The effect of homogenization, few steps and simple process

Inactive Publication Date: 2012-06-06
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the preparation of nano-lipid particles disclosed in China is mainly used for coating active ingredients of medicines, and few are used for coating active ingredients of cosmetics, and the preparation of coating sunscreens has not yet been published

Method used

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  • Nanometer lipid sun-prevention microparticle suspending liquid and preparation method thereof
  • Nanometer lipid sun-prevention microparticle suspending liquid and preparation method thereof
  • Nanometer lipid sun-prevention microparticle suspending liquid and preparation method thereof

Examples

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Effect test

example 1

[0041] Weigh 3.0g monoglyceride, 5.0g PEG-20 sorbitan monooleate, 4.0g caprylic capric triglyceride, 3.0g octyl methyl cinnamate, 2.0g menthyl anthranilate in oil Then weigh 83.0g of distilled water into the water phase beaker, heat the oil phase and the water phase to 85°C respectively, and at the same time homogenize the water phase at 8000 rpm, pour the components of the oil phase into the homogeneous After 2 minutes, start stirring and cooling at a stirring speed of 100 rpm. When the temperature of the system drops to 40°C, add 0.2g of imidazolidinyl urea, then stir and cool to room temperature 25°C.

example 2

[0043] Weigh 2.0g monoglyceride, 5.0g sorbitan monooleate, 2.0g isopropyl palmitate, 2.0g menthyl anthranilate, 4.0g 2-hydroxy-4-methoxybenzophenone In the beaker of the oil phase; then weigh 85.0g of distilled water in the beaker of the water phase, heat the oil phase and the water phase to 90°C respectively, and pour the oil phase components into the water phase at 10,000 rpm while homogenizing, After homogenizing for 3 minutes, start stirring and cooling at a stirring speed of 300 rpm. When the system cools down to 50°C, add 0.2g of phenoxyethanol, then stir and cool to room temperature 30°C.

example 3

[0045] Weigh 2.0g monoglyceride, 4.0g PEG-20 sorbitan monostearate, 4.0g isopropyl palmitate, 4.0g N,N-dimethyl-p-aminobenzoic acid octyl, 2.0g Put 4-methyl-4-ethoxybenzoylmethane in the beaker of the oil phase; weigh 84.0g of distilled water in the beaker of the water phase, heat the oil phase and the water phase to 80°C respectively, and mix at 15000 rpm At the same time as the water phase, pour in the oil phase components, after 4 minutes of homogenization, start to stir and cool, the stirring speed is 600 rpm, when the system cools down to 60°C, add 0.2g of imidazolidinyl urea, and then stir Cool to room temperature 25°C.

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Abstract

The invention discloses nanometer lipid sunblocking particle suspension fluid and a preparation method thereof. The nanometer lipid sunblocking particle suspension fluid consists of a UVA sunscreen agent, a UVB sunscreen agent, solid lipid, an emulsifier, a preservative and water. The preparation method comprises the following steps: the solid lipid, the emulsifier and the sunscreen agents are melted and dispersed evenly at a temperature of between 65 and 95 DEG C to obtain an evenly dispersed oil phase, and components of the oil phase are mixed evenly with water and then are cooled down to finally form the nanometer lipid sunblocking particle suspension fluid. In order to prevent the permeability of the chemical sunscreen agents on the skin, the particle diameter of lipid particles can not be too small; the lipid particles can be prepared through a common homogenous technology; and the preparation method has a simple process, few steps, and an easily controlled course. The method avoids high-pressure homogenizing and has safer operation. The particle diameter of the particles in the nanometer lipid sunblocking particle suspension fluid is between 80nm and 500nm, wherein the particle diameter between 100nm and 300nm is preferred. The nanometer lipid sunblocking particle suspension fluid has a sunscreen function within the wavelength coverage between 290nm and 400nm.

Description

technical field [0001] The invention relates to a suspension of nano lipid sunscreen particles and a preparation method thereof. Background technique [0002] Chemical sunscreens mainly refer to organic compounds that can absorb harmful ultraviolet radiation, usually called chemical ultraviolet absorbers. According to the different wavelength bands of protective radiation, UV (ultraviolet) absorbers can be divided into two types: UVA (living ultraviolet rays) and UVB (outdoor ultraviolet rays). From the chemical structure, it can be divided into p-aminobenzoic acid and its esters, salicylate and its derivatives, anthranilate, benzophenone and its derivatives, p-methoxycinnamic acid, methane Derivatives etc. The chemical sunscreens used in cosmetics will have certain side effects due to their photoinstability and skin irritation. In the EU, some sunscreens are restricted raw materials, while some sunscreens are banned raw materials. At the same time, general sunscreens onl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/98A61K8/45A61K8/85A61K8/86A61K8/44A61K8/35A61K8/36A61K8/37A61K8/04A61Q17/04
Inventor 张婉萍牛庆华曹磊昌
Owner SHANGHAI INST OF TECH
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