Medicine composition for treating polycystic kidney disease and use thereof
A technology for polycystic kidney disease and composition, applied in the field of pharmaceutical composition and its application and pharmaceutical preparations containing it, can solve problems such as weight gain, liver damage, and increased incidence of heart failure
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Embodiment 1
[0043] To observe the renal protective effects and side effects of long-term application of rosiglitazone, amiloride and their combination on ADPKD animal model Han: SPRD rats.
[0044] Experimental materials and methods
[0045] ADPKD animal model Han: SPRD rats were imported from the Mayo Clinic Medical Center in the United States and have been bred stably in the Experimental Animal Center of the Second Military Medical University for nearly 7 years. The inventor took Han:SPRD male 3-week-old heterozygous cy / + rats as intervention objects, and set up negative control group, rosiglitazone group (0.56mg / kg.d), amiloride group (0.35mg / kg .d) and 5 combined medication groups: amiloride+rosiglitazone (0.35mg / kg.d+0.56mg / kg.d), amiloride+rosiglitazone (0.175mg / kg.d +0.56mg / kg.d), amiloride+rosiglitazone (0.35mg / kg.d+1.12mg / kg.d), amiloride+rosiglitazone (0.35mg / kg.d +0.28mg / kg.d), amiloride+rosiglitazone (0.70mg / kg.d+0.56mg / kg.d). Gastrointestinal administration for 5 months, o...
Embodiment 2
[0064] Embodiment 2: Compound (amiloride hydrochloride+rosiglitazone maleate) solution
[0065] Prescription: Amiloride Hydrochloride 2.5g
[0066] Rosiglitazone Maleate 5g
[0067] Sodium Lauryl Sulfate 0.1g
[0068] Distilled water Appropriate amount to 10000m1
[0069] Process: Take the above-mentioned amiloride hydrochloride, rosiglitazone maleate and sodium lauryl sulfate, add 1000ml of distilled water to dissolve, then add distilled water to 10000ml to obtain.
Embodiment 3
[0070] Embodiment 3: Compound (amiloride hydrochloride + rosiglitazone maleate) syrup
[0071] Prescription: Amiloride Hydrochloride 1g
[0072] Rosiglitazone Maleate 2g
[0073] Distilled water 1500ml
[0074] Add simple syrup to 10000ml
[0075] Process: Dissolve amiloride hydrochloride and rosiglitazone maleate in distilled water, add simple syrup to the full amount, and obtain.
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