Compound doxycycline hydrochloride injection for animals and preparation method thereof
A technique for doxycycline hydrochloride and injection, which is applied in the field of veterinary compound doxycycline hydrochloride injection and its preparation, can solve the problems that the curative effect cannot be fully produced, and achieve long action time, low drug resistance, and long course of treatment. short effect
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Embodiment 1
[0031] A compound doxycycline hydrochloride injection for veterinary use contains the following components:
[0032] Doxycycline hydrochloride 5g, thiamphenicol 8g, trimethoprim 3.25g, diclofenac sodium 3g, dexamethasone sodium phosphate 0.05g, magnesium chloride 2.35g, sodium formaldehyde sulfoxylate 0.25g, sodium thiosulfate 0.15 g, 30g of α-pyrrolidone, 38g of N,N-dimethylformamide, 16g of water for injection; 2.4g of ethanolamine, a pH regulator, is required during the preparation process.
[0033] The preparation method of the veterinary compound doxycycline hydrochloride injection, the steps are as follows:
[0034] 1) After dissolving magnesium chloride in 8 g of water for injection, add 30 g of α-pyrrolidone, then add 5 g of doxycycline hydrochloride, and stir to dissolve;
[0035] 2) After dissolving sodium formaldehyde sulfoxylate in 3 g of water for injection, add it to the solution prepared in step 1), and then add 2 g of ethanolamine;
[0036] 3) After dissolvin...
Embodiment 2
[0052] A kind of veterinary compound doxycycline hydrochloride injection, raw material components are as follows:
[0053] Doxycycline hydrochloride 7g, thiamphenicol 10g, trimethoprim 4.3g, diclofenac sodium 4g, dexamethasone sodium phosphate 0.07g, magnesium chloride 3.3g, sodium formaldehyde sulfoxylate 0.5, sodium thiosulfate 0.20g , 35g of α-pyrrolidone, 40g of N,N-dimethylformamide, 10g of water for injection; 3g of ethanolamine, a pH regulator, is required during the preparation process.
[0054] The preparation steps are the same as in Example 1.
Embodiment 3
[0056] A compound doxycycline hydrochloride injection for veterinary use contains the following components:
[0057] Doxycycline hydrochloride 3g, thiamphenicol 6g, TMP1.6g, diclofenac sodium 2g, dexamethasone sodium phosphate 0.03g, magnesium chloride 1.4g, sodium formaldehyde sulfoxylate 0.1g, sodium thiosulfate 0.10g, α - 25g of pyrrolidone, 45g of N,N-dimethylformamide, 20g of water for injection; 1.5g of ethanolamine, a pH regulator, is required during the preparation process.
[0058] The preparation steps are the same as in Example 1.
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