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Cinnamomum kanehirae Hayata pimelie kelone compound for liver protection

A technology of cyclohexenone and compound, applied in the field of cyclohexenone compound, can solve unpublished specific problems and the like

Inactive Publication Date: 2009-03-04
GOLDEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although it can be known from many current experiments that the extract of Antrodia Cinnamomea has the aforementioned effects, and its constituents have been analyzed one after another, no specific research has been published on which active ingredients in the extract can contribute to the liver-protecting effect of Antrodia Cinnamomum. The relevant active ingredients need to be clarified by further experimental research. Therefore, if the real effective liver-protecting ingredients contained in the extract can be found, it will be beneficial to the research on the mechanism of Antrodia Cinnamomea protecting the liver and the application of Antrodia Cinnamomea in the treatment of liver-related diseases. Helps a lot with prevention

Method used

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  • Cinnamomum kanehirae Hayata pimelie kelone compound for liver protection
  • Cinnamomum kanehirae Hayata pimelie kelone compound for liver protection
  • Cinnamomum kanehirae Hayata pimelie kelone compound for liver protection

Examples

Experimental program
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Effect test

Embodiment 1

[0028] 4-Hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-2,6,10-dodecatriene)-2-cyclohexenone separate

[0029] Put about 100 grams of Antrodia antrodia mycelia, fruiting bodies or a mixture of the two into a conical flask, add an appropriate proportion of water and alcohols (for example, an aqueous alcohol solution of more than 70%, at 20-25°C Stir and extract for at least 1 hour, then filter through filter paper and a 0.45 μm filter membrane to collect the extract.

[0030] The Antrodia camphorata extract collected above was analyzed using a high performance liquid chromatography (High Performance Liquid chromatography) with an RP18 column (column), and methanol (A) and 0.1% to 0.5% acetic acid aqueous solution (B) ) as the mobile phase (the solution ratio is: 0 to 10 minutes, B ratio is 95% to 20%; 10 to 20 minutes, B ratio is 20% to 10%; 20 to 35 minutes, B ratio 10% to 90%; 35 to 40 minutes, the proportion of B is 10% to 95%), eluting at a speed of 1ml per minute, and...

Embodiment 2

[0033] Hepatoprotective Test of Cyclohexenone Compounds from Antrodia Antrodia

[0034] Since the main factors causing liver disease are viral, alcoholic and chemical, and the pathological phenomenon in the pathological section of the mouse animal model is consistent with that of the human body, it is chemical liver injury, so this evaluation method is aimed at chemical liver injury. Hepatoprotective function assessment for acute liver injury; through carbon tetrachloride (CCl 4 ) induced an experimental model of chronic liver injury in rats, and detected the biochemical values ​​of liver injury and liver tissue slices to explore the effect of the treatment of Antrodia antrodia cyclohexenone compound on chronic liver injury in rats. Among them, the toxicity of carbon tetrachloride can cause necrosis of liver cells, and further develop into liver fibrosis (fibrosis), and if it is continuously administered, it will cause irreversible liver cirrhosis (cirrhosis); the principle of...

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Abstract

The invention relates to an Antrodia Camphorata cyclohexanone compound for protecting the liver, particularly 4-hydroxy-2,3-dimethoxy-6-methy-5[3,7,11- trimethyl-dodeca-2,6,10-trienyl]-cyclohex-2-enone separated from an Antrodia Camphorata extract and capable of effectively protecting the liver. The Antrodia Camphorata cyclohexanone compound is conducive to alleviating the injury of the liver tissue due to the chemical liver injury and the fiberization extent, and can reduce the concentrations of alanine aminotransferase (ALT) and aspartic acid (AST), increase the contents of glutathione peroxidase (GSHPx) and catalase (CAT) in the liver and reduce the injury of free radicals to liver cells so as to improve the oxidization resistance of the liver tissue and further protect the liver.

Description

technical field [0001] The present invention relates to a compound for protecting the liver, in particular to a cyclohexenone compound isolated and purified from the extract of Antrodia camphorata and used for protecting the liver and slowing down liver damage and fibrosis . Background technique [0002] The liver is the largest and most complex important metabolic organ in the human body. It plays an important role in the metabolism of sugar, lipid, protein, vitamins, hormones, bile and other substances; Function: The liver is also an important barrier organ of the body, and its detoxification function has an important protective effect on the body. Therefore, when the liver function is damaged, it will cause metabolic disorders and affect the functions of other organs, and in severe cases, it will be life-threatening. The prevalence rate of liver disease among Chinese people is very high. According to statistics from the Department of Health of the Executive Yuan, chronic...

Claims

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Application Information

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IPC IPC(8): C07C49/517C07C45/78A61K31/122A61P1/16
CPCA61K31/122A61P1/16
Inventor 刘胜勇温武哲郭茂田
Owner GOLDEN BIOTECH
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