Method for preparing sweet clover extract and medicinal value thereof
A technology for extracts and extracts of the yellow flower, Trichosanthes chinensis, is applied in the development field of pharmaceutical preparations, and can solve problems such as unsatisfactory effects and the like
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Embodiment 1
[0008] Weigh 1Kg of sweet-scented clover, crush it into coarse powder, add organic solvent ethyl acetate, heat and reflux in 80°C water bath to extract 3 times, each time for about 1.5 hours, and combine the filtrate; after concentrating the filtrate, dry it in an oven at 60°C to obtain the grass 34g of sweet-scented osmanthus extract (the contents of polyphenols, flavonoids and coumarins in the extract are 3.2%, 1.2%, and 5.3%, respectively). Drug efficacy experiments have shown that the ethyl acetate extract of sweet clover has very good analgesic, anti-inflammatory and hemostatic effects. Anti-inflammatory experiments showed that when 240mg / Kg of drugs were applied to the xylene-induced mouse ear swelling model (the following drugs were calculated based on the amount of extract extract), it could significantly reduce the xylene-induced mouse ear swelling (P<0.01 ); application of 120mg / Kg of the drug can significantly reduce xylene-induced mouse auricle swelling (P<0.05). ...
Embodiment 2
[0010] Weigh Melilotus 1Kg, crush it into a coarse powder, add an appropriate amount of solvent ethyl acetate to ultrasonically extract 3 times, each time about 0.5h, and combine the filtrate; after concentrating the filtrate, dry it in a 60°C oven to obtain 43g of Melilotus extract ( The contents of polyphenols, flavonoids and coumarins in the extract are 3.4%, 1.6%, 5.8%, respectively). It can be made into various types of preparations with auxiliary materials, and the finished products of this extract also have strong analgesic, anti-inflammatory, and hemostatic effects. Anti-inflammatory experiments showed that when 240mg / Kg of xylene-induced mouse ear swelling model was applied, it could significantly reduce xylene-induced mouse ear swelling (P<0.01); Toluene induced ear swelling in mice (P<0.05). Analgesic experiments showed that when the drug was applied at 120mg / Kg, the number of writhing in mice could be significantly reduced (P<0.01); when the drug at 60mg / Kg was ap...
Embodiment 3
[0012] Weigh 1Kg of sweet-scented osmanthus, crush it into coarse powder, add organic solvent ethanol in a water bath at 80°C, reflux extract 3 times, about 1.5 hours each time, combine the filtrate; concentrate the filtrate and dry it in an oven at 60°C to obtain sweet-scented sweet-scented osmanthus 52g of the extract (the contents of polyphenols, flavonoids and coumarins in the extract are 2.2%, 3.8%, and 0.97%, respectively). It is made into tablets with auxiliary materials. Drug efficacy experiments show that the ethanol extract of sweet clover has very good analgesic and hemostatic effects, and has anti-Staphylococcus aureus effect, but the anti-inflammatory effect is unstable. Anti-inflammatory experiments showed that when 300 mg / Kg of xylene-induced auricle swelling was applied to the mouse auricle swelling model, it could significantly reduce xylene-induced mouse auricle swelling (P<0.01); Toluene induced ear swelling in mice (P<0.05). The analgesic experiment showe...
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