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Preparation method for reactive chitosan derivant

A technology of chitosan derivatives and reactivity, which is applied in the field of preparation of natural biopolymer materials, can solve the problems of complex process, high cost, and low degree of product substitution, and achieve simple experimental equipment, easy reaction process, and wide application Effect

Inactive Publication Date: 2009-02-18
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a chitosan modification method with low cost, simple process, high product substitution and less prone to degradation, aiming at the disadvantages of high cost, complex process, low product substitution degree and easy degradation in the prior art chitosan modification method. Preparation method of degraded reactive chitosan derivatives

Method used

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  • Preparation method for reactive chitosan derivant
  • Preparation method for reactive chitosan derivant

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Add 2.0g of chitosan (DP=85%, Mw=100,000) into 200mL of a solution of triethylamine and chloroform with a volume ratio of 1:1, stir at room temperature for 48 hours, and place it on ice at -5°C Cool and stir under the bath for 2 hours, dissolve 1.24g of methacryloyl chloride in 20mL of chloroform, stir evenly, slowly add it dropwise to the chitosan solution under the ice bath condition of -5°C, and react for 2 hours. Continue to react at normal temperature for 6 hours, and wash the filtered precipitate three times with acetone to obtain the reactive chitosan derivative.

Embodiment 2

[0025] Add 2.0 g of chitosan (DP=85%, Mw=100,000) to 200 mL of a solution of triethylamine and dichloromethane at a volume ratio of 1:1, stir at room temperature for 48 hours, and place it on ice at -5°C Cool and stir in the bath for 2 hours, dissolve 2.2g of acryloyl chloride in 30mL of dichloromethane, stir evenly, and slowly add it dropwise to the chitosan solution under the ice bath condition of -5°C, react for 3 hours, and continue to React at normal temperature for 6 hours, and wash the filtered precipitate three times with acetone to obtain the reactive chitosan derivative.

Embodiment 3

[0027] Add 2.0g of chitosan (DP=85%, Mw=200,000) to 200mL of a solution of ethylamine and dichloromethane at a volume ratio of 2:1, stir at room temperature for 48 hours, and place in an ice bath at -5°C Under cooling and stirring for 2 hours, dissolve 1.5g of acryloyl chloride in 20mL of dichloromethane, stir evenly, and slowly add it dropwise to the chitosan solution in an ice bath at -5°C, react for 3 hours, and continue to The reaction was carried out for 6 hours, and the filtered precipitate was washed three times with acetone to obtain the reactive chitosan derivative.

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Abstract

The invention relates to a preparation method of reactive chitosan derivatives, comprising adding chitosan in the mixture solution of organic amine and chloralkane or organic amine and acetone with the volume ratio of 1 to 3:1, stirring and placing for 48 hours at room temperature, cooling and stirring for 2 hours in ice bath at 5 DEG C below zero, dripping the chloralkane solution of 40 to 60wt% of unsaturated acyl chloride in the mixture solution within 2 to 4 hours, continuing to react for 6 hours at room temperature, wherein, the dripped long chain acyl chloride is 2 to 4 times of the mole number of the chitosan, obtaining the reactive chitosan derivative containing a double bond. The method of the invention realizes the solution of the chitosan derivative in organic solvents. The chitosan derivative can react and polymerize under ultraviolet light. The preparation method of reactive chitosan derivatives has the advantages of strong reaction process controllability, simple equipment and easy reaction process operation. The industrialization of products can be realized.

Description

technical field [0001] The invention relates to a preparation method of reactive N, O-chitosan derivatives. The invention belongs to the field of preparation of natural biopolymer materials. Background technique [0002] Chitin is the second largest natural biopolymer in storage after cellulose in nature. Chitosan is the product of deacetylation of chitin after chemical treatment. It is an environmentally friendly natural polymer. Chitosan has the advantages of non-toxic antibacterial and anti-inflammatory, good biocompatibility, and strong biodegradability. At the same time, chitosan has many excellent properties such as anticancer, hemostatic, and immune enhancement. Therefore, it has great application value in food, cosmetics, packaging materials, textile printing and dyeing, oil field treatment, agricultural applications, etc., especially in the field of biomedical materials, it can be used as burn dressings, postoperative adhesion materials, drug carriers, enzyme inhib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 聂俊马贵平杨冬芝
Owner BEIJING UNIV OF CHEM TECH
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