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Acarbose chewable tablets and preparation method thereof

A technique for acarbose and chewable tablets, which is applied in the field of chewable tablets containing acarbose as an active ingredient and its preparation, can solve the problems of easy moisture absorption and poor taste, and achieve moisture resistance, stable drug effect, and convenience carrying effect

Active Publication Date: 2009-01-07
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defects of the existing common tablets of acarbose preparations such as easy moisture absorption and poor mouthfeel, and provide a chewable acarbose tablet with stable drug effect, good mouthfeel and convenient taking

Method used

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  • Acarbose chewable tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription:

[0030] Acarbose 50g

[0031] Sorbitol 90g

[0032] Microcrystalline Cellulose 20g

[0033] 5% polyethylene glycol ethanol solution appropriate amount

[0034] Pineapple Flavor 4g

[0035] Magnesium stearate 2g

[0036]

[0037] Made into 1000 pieces

[0038] The raw and auxiliary materials of the above-mentioned prescription amount were weighed and passed through 80 mesh sieves respectively, polyethylene glycol was prepared into a 5% solution with ethanol for later use, acarbose, sorbitol, and microcrystalline cellulose were mixed evenly, and an appropriate amount of 5% polyethylene glycol was added. Ethylene glycol ethanol solution is used to moisten the material so that the material reaches the state of "agglomeration when grasped and disperse when touched", that is, it is made into a soft material, granulated through a 20-mesh sieve, dried at 45°C, and then granulated through a 24-mesh sieve. The dry granules are mixed w...

Embodiment 2

[0040] prescription:

[0041] Acarbose 50g

[0042] Mannitol 350g

[0043] 5% ethyl cellulose ethanol solution appropriate amount

[0044] Micronized silica gel 4g

[0045] Magnesium Stearate 4g

[0046]

[0047] Made into 1000 pieces

[0048] The raw and auxiliary materials of the above-mentioned prescription amount were weighed and passed through 80 mesh sieves, and prepared into 5% ethyl cellulose ethanol solution for use. Acarbose, mannitol, and microcrystalline cellulose were mixed evenly, and an appropriate amount of 5% ethyl cellulose was added. Moisten the cellulose ethanol solution to make the material reach the state of "agglomerate when grasped and disperse when touched", that is, it is made into a soft material, granulated through a 20-mesh sieve, dried at 60°C, and then granulated through a 24-mesh sieve. The dry granules are mixed with micronized silica gel and magnesium stearate, mixed evenly, and then compressed into capsule-sh...

Embodiment 3

[0050] prescription:

[0051] Acarbose 50g

[0052] Mannitol 700g

[0053] Microcrystalline Cellulose 200g

[0054] Micronized silica gel 20g

[0055] Magnesium Stearate 10g

[0056] Red Yeast Pigment 20g

[0057]

[0058] Made into 1000 pieces

[0059] Weigh the raw and auxiliary materials of the above prescription amount, pass through 80-mesh sieve respectively, mix acarbose, mannitol, microcrystalline cellulose, micropowder silica gel, and monascus pigment evenly, then add magnesium stearate, mix evenly, and then directly press into diamond-shaped slices.

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Abstract

The invention discloses an acarbose chewable tablet comprising a bulking agent and a lubricating agent. The inventive acarbose chewable tablet overcomes the drawback that acarbose is not easy to make into chewable tablet and overcomes the shortcomings of acarbose common tablet including high moisture absorption liability and unpleasant feeling during administration by optimization of specific adjuvants, so as to remarkably improve the compliance of patients while ensuring the drug effect. The invention also discloses a preparation method of the acarbose chewable tablet, which has the advantages of good stability and feasibility, simple process, controllable product quality and applicability to industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a chewable tablet containing acarbose as an active ingredient and a preparation method thereof. Background technique [0002] Diabetes is a common endocrine and metabolic disorder, and it is regarded as the three major diseases in the world together with cancer and cardiovascular disease. With the improvement of people's living standards, the number of diabetic patients is gradually increasing, especially type 2 diabetes, that is, non-insulin-dependent diabetes, which has shown a rapid upward trend in recent years. According to the survey, diabetic patients account for about 1-2% of the total population, and type 2 diabetic patients account for more than 90%. It is estimated that there are more than 120 million diabetic patients in the world, and there are nearly 40 million diabetic patients in China. In 2015, the prevalence of diabetes in my country will reach 10%. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7034A61P3/10
Inventor 方国林
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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