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Losartan potassium and hydrochlorothiazide tablets and preparation method thereof

A technology of losartan potassium hydrochlorothiazide tablets and losartan potassium, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc. Low, long disintegration time and other problems, to achieve the effect of good dissolution rate, good dissolution rate and good stability of the tablet

Active Publication Date: 2008-12-24
HAINAN JINRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of the preparation technology and dosage forms of these conventional preparations, such oral preparations have disadvantages such as long disintegration time, slow onset of action, and low bioavailability, which affect the full play of the drug effect.

Method used

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  • Losartan potassium and hydrochlorothiazide tablets and preparation method thereof
  • Losartan potassium and hydrochlorothiazide tablets and preparation method thereof
  • Losartan potassium and hydrochlorothiazide tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Prescription:

[0057] Tablet prescription:

[0058] Losartan Potassium 50mg

[0059] Hydrochlorothiazide 12.5mg

[0060] Microcrystalline Cellulose 80mg

[0061] Lactose monohydrate 80mg

[0062] Pregelatinized starch 12mg

[0063] Povidone K30 2.4mg

[0064] Magnesium Stearate 2.4mg

[0065]

[0066] Total 239.3mg

[0067] Coating Solution Prescription:

[0068] 7.2mg

[0069] Purified water 36mg

[0070] (2) Preparation method:

[0071] (a) mixing losartan potassium, hydrochlorothiazide, and lactose monohydrate;

[0072] (b) Povidone K30 is dissolved in 75% ethanol;

[0073] (c) Mix the product obtained in step (a) and step (b) uniformly, granulate with a 24-mesh sieve, dry at 60° C., pass the dry granules through a 24-mesh sieve for granulation;

[0074] (d) mixing the product obtained in step (c) with microcrystalline cellulose, pregelatinized starch, and magnesium stearate evenly, measuring the content of th...

Embodiment 2

[0077] (1) Prescription:

[0078] Tablet prescription:

[0079] Losartan Potassium 40mg

[0080] Hydrochlorothiazide 10mg

[0081] Microcrystalline Cellulose 70mg

[0082] Lactose monohydrate 70mg

[0083] Pregelatinized starch 10mg

[0084] Povidone K30 2mg

[0085] Magnesium Stearate 2mg

[0086] Coating Solution Prescription:

[0087] 7.2mg

[0088] Purified water 36mg

[0089] (2) Preparation method:

[0090] (a) mixing losartan potassium, hydrochlorothiazide, and lactose monohydrate;

[0091] (b) Povidone K30 is dissolved in 75% ethanol;

[0092] (c) Mix the product obtained in step (a) and step (b) uniformly, granulate with a 24-mesh sieve, dry at 60° C., pass the dry granules through a 24-mesh sieve for granulation;

[0093] (d) Mix the product obtained in step (c) with microcrystalline cellulose, pregelatinized starch, and magnesium stearate evenly, measure the content of the main ingredient, and press the tablet after determining the weight of...

Embodiment 3

[0095] (1) Prescription:

[0096] Tablet prescription:

[0097] Losartan Potassium 60mg

[0098] Hydrochlorothiazide 15mg

[0099] Microcrystalline Cellulose 90mg

[0100] Lactose monohydrate 90mg

[0101] Pregelatinized Starch 14mg

[0102] Povidone K30 2.8mg

[0103] Magnesium Stearate 2.8mg

[0104] (2) Preparation method:

[0105] (a) mixing losartan potassium, hydrochlorothiazide, and lactose monohydrate;

[0106] (b) Povidone K30 is dissolved in 75% ethanol;

[0107] (c) Mix the product obtained in step (a) and step (b) uniformly, granulate with a 24-mesh sieve, dry at 60° C., pass the dry granules through a 24-mesh sieve for granulation;

[0108] (d) Mix the product obtained in step (c) with microcrystalline cellulose, pregelatinized starch, and magnesium stearate evenly, measure the content of the main ingredient, and press the tablet after determining the weight of the tablet. Compression under the condition of humidity 65%;

[0109] (e) Put the tablet prep...

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Abstract

The invention relates to a losartan potassium hydrochlorothiazide tablet and a preparation method thereof. The losartan potassium hydrochlorothiazide tablet comprises a core and a film coat layer and is characterized in that the core is composed of the losartan potassium and the hydrochlorothiazide which serve as the medicinal active components, and a medicinally available accessory. The medicinally available accessory is microcrystalline cellulose, pregelatinized starch, lactose monohydrate, polyvinylpyrrolidone K30 and magnesium stearate. The preparation method of the losartan potassium hydrochlorothiazide tablet is as the following: the hydrochlorothiazide is mixed with the easily-dissolvable losartan potassium and lactose monohydrate, and then the mixture is made into grains; the hydrochlorothiazide is dispersed in the easily-dissolvable losartan potassium and lactose monohydrate, and then mixed with the microcrystalline cellulose, the pregelatinized starch and magnesium stearate; then tablets are made and coated. The tablet hydrochlorothiazide prepared according to the method of the invention dissolves out well and has no moisture absorption under high moisture conditions.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and particularly relates to a losartan potassium hydrochlorothiazide tablet prepared from chemical raw materials losartan potassium (Losartan Potassium), hydrochlorothiazide (Hydrochrothiazide) and pharmaceutically acceptable auxiliary materials. Background technique [0002] Hypertension is one of the most common cardiovascular diseases in the world today and the leading cause of death and disability in adults. Due to the improvement of people's living standards and the increasingly tense job competition, the number of patients with hypertension has greatly increased. The prevalence of hypertension in my country has increased significantly. According to statistics in China, the incidence of hypertension among people aged 35 to 70 in China is as high as 27%, and the number of patients is close to 130 million. And with the annual growth rate of more than 300 million people, my country has become ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/41A61K31/5415A61K47/38A61P9/12
Inventor 王小树
Owner HAINAN JINRUI PHARMA
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