Stress evaluation and intervention method of laboratory animal short-distance transport

Abstract

The invention belongs to the experimental animal field and relates to a method for evaluating and intervening the experimental animal short-distance transportation stress. By observing the effect of the short-distance transportation stress on the experimental animals, the method establishes the short-distance transportation stress evaluation, comprises technology index systems such as energy metabolism totem GLU, immunologic function executor WBC, HPA axial final effect laser CORT, etc., ensures that the health adaptive stage after the short-distance transportation stress is at least 72 hr and provides the nutrition replenisher intervention measure for relieving the adverse reaction of the short-distance transportation stress. The method can provide the experiment basis for scientification and standardization of the experimental animal short-distance transportation, avoid the damage to the health and the wellbeing of the experimental animals caused by the short-distance transportationstress and the background disturbance thereof, solve the actual problems with production and linkage and ensure the scientificity and the validity of the biomedical scientific research and the product certification.

Description

technical field [0001] The invention belongs to the field of experimental animals and relates to short-distance transport of experimental animals, in particular to a stress evaluation and intervention method for short-distance transport of experimental animals. Background technique [0002] Experimental rats and mice are the most widely used experimental animals in life science research and biomedical product verification, accounting for about 80% of the total number of experimental animals used. According to reports, the United States, Europe, and Japan use about 25 million experimental rats and mice every year. In the United Kingdom alone, the number of experimental rats and mice used in 2000 reached 2141,935. With the rapid development of life sciences and the rapid expansion of the pillar industries of biomedicine, the annual use of experimental rats and mice in my country has reached more than 10 million. [0003] In foreign countries, due to the maturing of social div...

AI Technical Summary

Problems solved by technology

Due to the impact of short-distance transportation stress, the physiological conditions and functional indicators of animals vary. After arriving at the destination, a considerable health adaptation period (period of acclimatization following transportation) is required for recuperation and adjustment. It can only be used in experiments after recovery, otherwise not only It will cause background interference to animal experiments, affect the authenticity and reliability of scientific research and the safety and effectiveness of biomedical product testing, and also damage the welfare and health of experimental animals

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