Applications of betaine in preparing medicament for preventing and treating alimentary obesity

A technology of betaine and medicine, which is applied in the application field of betaine in the prevention and treatment of dietary obesity, can solve the problems that have not been seen in the prevention and treatment of dietary obesity with betaine, and achieve the prevention of dietary obesity and the inhibition of adipocyte differentiation Effect

Inactive Publication Date: 2008-12-17
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there have been no reports on the prevention and treatment of dietary obesity with betaine

Method used

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  • Applications of betaine in preparing medicament for preventing and treating alimentary obesity
  • Applications of betaine in preparing medicament for preventing and treating alimentary obesity
  • Applications of betaine in preparing medicament for preventing and treating alimentary obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Using Atlantis HILIC Silica chromatographic column (analytical grade) to analyze the component Hx in the extract of Chinese medicine Rehmannia glutinosa.

[0026] Waters Alliance chromatographic system: including 2690 separation unit, 2487 ultraviolet detector, Masslynx4.0 chromatographic management system, Waters ZQ 2000 mass spectrometer; acetonitrile (Fisher), ultrapure water (Millipore), formic acid (Shanghai Chemical Reagent Factory).

[0027] Chromatographic conditions for separating component Hx: Atlantis HILIC Silica Column (2.1mm i.d.×150mm, 4μm), mobile phase A: 0.1% formic acid in water, mobile phase B: 0.1% formic acid in acetonitrile, gradient program: from 0 to In the first 10 minutes, it rises linearly from 30% A to 50% A, and in the 10th to 25th minutes, it returns to 30% A, and the flow rate is 0.2ml / min. The sample chamber temperature and column temperature were 10°C and 20°C, respectively. The wavelength of the 2487 UV detector was set at 254nm an...

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Abstract

The invention belongs to the technical field of the traditional Chinese medicines and relates to the new medicinal application of betaine, in particular to the application of betaine on the treatment and prevention of dietary obesity. The betaine described in the invention is one of the ingredients of radix rehmanniae extract. Proved by animal tests, the betaine can inhibit differentiation of fat cells and the expression of key transcription factors in the differentiation of fat cells; the proliferation of fat cells can be restrained when the differentiation of fat cells is inhibited; moreover, the betaine can prevent weight gain induced by high fat diet, raise high density lipoprotein level in plasma and reduce low density lipoprotein in plasma, thus the betaine can be used for preparing the drugs for preventing and treating dietary obesity.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a new medicine application of betaine, more specifically, the invention relates to the application of betaine in preventing and treating dietary obesity. Background technique [0002] Betaine is a natural compound, non-toxic, harmless, and stable in nature, widely distributed in animals and plants. In the 1960s, studies found that betaine had a significant regulatory effect on methyl metabolism in rats, so it was used as a specific drug for methyl donors to treat human congenital cystinuria. In recent years, with the continuous deepening of research on betaine in animal nutrition, it has been confirmed that betaine is an important methyl donor in animal organisms, participates in amino acid and fat metabolism, and has the effects of promoting growth and improving carcass composition. [0003] Studies have shown that the main effects of betaine ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/205A61P3/04
Inventor 宋后燕莫炜江霖
Owner FUDAN UNIV
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