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Compound gelling agent containing clindamycinum

A compound gel, clindamycin technology, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, pharmaceutical formulas, etc., can solve the problem of increasing the difficulty of gel detection and the interference of carbomer determination. , uneven gel dispersion and other problems, to achieve the effect of being conducive to detection and quality control, saving preparation time, and simple preparation

Active Publication Date: 2008-10-29
CHONGQING PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Since clindamycin and its pharmaceutically acceptable salts or esters are extracted from microbial fermentation broth, the impurities are very complicated. If the polymer material selected for the preparation of the gel is inappropriate, especially carbomer will encounter Measuring Interference Problems
Moreover, since clindamycin and its pharmaceutically acceptable salts or esters are highly water-soluble substances, but tretinoin is insoluble in water, different conditions must be used for detection, which also increases the difficulty of gel detection.
Due to its viscous nature, polymer materials can also cause problems such as uneven dispersion of the gel and clogging of the analytical chromatographic column.
Have not found the method that solves these problems at present, the present invention has adopted a kind of special detection method and can solve these problems

Method used

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  • Compound gelling agent containing clindamycinum
  • Compound gelling agent containing clindamycinum
  • Compound gelling agent containing clindamycinum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] In the first step, first dissolve 0.8 grams of dibutyl hydroxytoluene and 0.2 grams of tretinoin in 240 grams of absolute ethanol, then add 16.0 grams of sodium carboxymethylcellulose, stir at 120 rpm to disperse it evenly, and obtain a component;

[0102] In the second step, 9.6 grams of clindamycin phosphate and 0.4 grams of citric acid were dissolved into 533 grams of distilled water to obtain component b;

[0103] In the third step, component b is slowly added to component a, and added while stirring to obtain a gel.

[0104] Clindamycin Phosphate Assay:

[0105] Take an appropriate amount of the prepared gel (approximately equivalent to 18 mg of clindamycin phosphate), weigh it accurately, put it in a 50 ml conical flask with a stopper, add about 5 ml of mobile phase, shake to disperse, and use the mobile phase to divide Wash into a 25ml volumetric flask, add mobile phase to dilute to the mark, shake well, put in a 15ml centrifuge tube, centrifuge at 4000 rpm per...

Embodiment 2

[0111] In the first step, first dissolve 0.8 grams of dibutyl hydroxytoluene and 0.2 grams of tretinoin in 80 grams of absolute ethanol, then add 16.0 grams of sodium carboxymethylcellulose, stir at 120 rpm to disperse it evenly, and obtain a component;

[0112] In the second step, 9.6 grams of clindamycin phosphate and 0.4 grams of citric acid were dissolved into 693 grams of distilled water to obtain component b;

[0113] In the third step, component b is slowly added to component a, and added while stirring to obtain a gel.

[0114] The detection method of clindamycin phosphate and tretinoin is the same as that in Example 1.

Embodiment 3

[0116] In the first step, 0.8 grams of dibutyl hydroxytoluene and 0.2 grams of tretinoin were dissolved in 400 grams of absolute ethanol, and then 16.0 grams of sodium carboxymethylcellulose was added, stirred at 120 rpm to disperse it evenly, and obtained a component;

[0117] In the second step, 9.6 grams of clindamycin phosphate and 0.4 grams of citric acid were dissolved into 373 grams of distilled water to obtain component b;

[0118] In the third step, component b is slowly added to component a, and added while stirring to obtain a gel.

[0119] The detection method of clindamycin phosphate and tretinoin is the same as that in Example 1.

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Abstract

The invention relates to compound gel containing clindamycin. The compound gels comprise effective dose of the clindamycin or medicinal salt or ester, Tretinoin and gel matrix. The invention is characterized in that the gel matrix is celluloses derivative, a preparation method as well as the detection and analysis methods of the gel are also related. The gel of the invention has the advantages of easy quality control, simple preparation technique and being suitable for industrial production.

Description

Technical field: [0001] The invention relates to a compound gel containing clindamycin or its pharmaceutically acceptable salt or ester, in particular to containing clindamycin or its pharmaceutically acceptable salt or ester, retinoic acid and cellulose derivatives The compound gel agent of the gel agent matrix and its preparation method and analysis and detection method. technical background: [0002] Acne is a common disease, affecting more than 90% of teenagers; even around 40 years old, about 5% of women and 1% of men suffer from it. Acne is prone to occur on people's faces, which not only brings pain to the patient's body, but also affects the patient's appearance, thereby bringing mental stress to the patient. Therefore, the drug market for the treatment of acne is promising, with an estimated market size of US$500-2 billion. At present, there are many kinds of acne drugs, and the market competition is becoming more and more fierce. Therefore, it is of great signifi...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K31/203A61K9/00A61K47/38A61P17/10
Inventor 林佳亮万娟张涛邓杰樊斌
Owner CHONGQING PHARMA RES INST
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