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Medicament automatic release system preparation method based on conductive polymer polypyrrole

A conductive polymer, automatic release technology, applied in non-active ingredients medical preparations, drug delivery, pharmaceutical formulations, etc., can solve the problems of complicated processing and sealing, increased energy consumption, etc.

Inactive Publication Date: 2008-10-29
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current drug release system using polypyrrole as a drug carrier requires a certain potential to release the drug. Therefore, only when the power supply is integrated in the system can it meet the requirements of its release in the body.
This not only increases energy consumption, but also complicates processes such as processing and sealing, which limits the further application of polypyrrole drug release technology to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Pretreatment of titanium sheet

[0021] Set the area to 150mm 2 , A titanium sheet with a thickness of 0.5mm, was ultrasonically treated with toluene, acetone, and absolute ethanol for 10 minutes in turn, then immersed in hydrofluoric acid for 30 seconds, and then ultrasonically treated with absolute ethanol for 10 minutes. 2 Blow dry.

[0022] 2) One-sided sealing of titanium sheet

[0023] One surface of the pretreated titanium sheet is sealed with an insulating material epoxy resin.

[0024] 3) Immobilization of sulfosalicylic acid

[0025] The single-sided sealed titanium sheet is immersed in an aqueous solution composed of pyrrole monomer (0.02mol / L) and sulfosalicylic acid (0.02mol / L). The titanium sheet is used as the working electrode, and the platinum electrode is the auxiliary electrode. The calomel electrode is a reference electrode. Under 1.1V polymerization potential, a polypyrrole film immobilized with sulfosalicylic acid is grown on the unsealed surface of...

Embodiment 2

[0031] 1) Pretreatment of titanium sheet

[0032] Set the area to 140mm 2 , 0.8mm thick titanium sheet, followed by ultrasonic treatment with toluene, acetone, and absolute ethanol for 10 minutes, then soaked in hydrofluoric acid for 30 seconds, and then ultrasonically treated with absolute ethanol for 10 minutes. Take it out with N 2 Blow dry.

[0033] 2) One-sided sealing of titanium sheet

[0034] One surface of the pretreated titanium sheet is sealed with an insulating material epoxy resin.

[0035] 3) Immobilization of sulfosalicylic acid

[0036] The single-sided sealed titanium sheet is immersed in an aqueous solution composed of pyrrole monomer (0.08mol / L) and sulfosalicylic acid (0.04mol / L). The titanium sheet is used as the working electrode, and the platinum electrode is used as the auxiliary electrode. The calomel electrode is a reference electrode. A polypyrrole film immobilized with sulfosalicylic acid is grown on the unsealed surface of the other side of the titaniu...

Embodiment 3

[0042] 1) Pretreatment of titanium sheet

[0043] Set the area to 120mm 2 , A titanium sheet with a thickness of 1.0mm, was ultrasonically treated with toluene, acetone, and absolute ethanol for 10 minutes in sequence, then immersed in hydrofluoric acid for 30 seconds, and then ultrasonically treated with absolute ethanol for 10 minutes, and then taken out with N 2 Blow dry.

[0044] 2) One-sided sealing of titanium sheet

[0045] One surface of the pretreated titanium sheet is sealed with an insulating material epoxy resin.

[0046] 3) Immobilization of sulfosalicylic acid

[0047] The single-sided sealed titanium sheet is immersed in an aqueous solution composed of pyrrole monomer (0.15 mol / L) and sulfosalicylic acid (0.05 mol / L). The titanium sheet is used as the working electrode, and the platinum electrode is the auxiliary electrode. The calomel electrode is a reference electrode. A polypyrrole film immobilized with sulfosalicylic acid is grown on the unsealed surface of the ...

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Abstract

The invention discloses a preparation method of an automatic drug release system based on electric conduction macromolecule polypyrrole and relates to a release technology of drug control, The invention provides a preparation method of the automatic drug release system based on electric conduction macromolecule polypyrrole, with polypyrrole as a drug carrier and without additional potential to automatically release the drug sulfosulicylic acid under body temperature. Surface insulating material of a pre-treated titanium sheet is sealed, and then the titanium sheet is immerged in the solution composed of pyrrole monomer and sulfosalicylic acid; polypyrrole film-supported sulfosulicylic acid is generated on the surface of the unsealed side of the titanium sheet by adopting an electrochemical method, the insulating material on the sealed side of the titanium sheet is removed and coated with a layer of eicosane, and then the final drug release system is obtained. The drug release system is placed in normal saline, phosphate buffer solution or simulated body fluid, the eicosane dissolves automatically after warming up to 36.8-37.5 DEG C, and polypyrrole film-supported sulfosulicylic acid can be automatically released to the solution successively.

Description

Technical field [0001] The invention relates to a drug controlled release technology, in particular to a method for preparing a drug release system using polypyrrole as a drug carrier. Background technique [0002] Polypyrrole is a conductive polymer. It has unique doping / dedoping properties. When it changes between the oxidized state and the reduced state, it will be accompanied by the process of doping ions entering and leaving the conductive polymer. Maintain charge balance (JM Pernaut, JR Reynolds, Journal of Physical Chemistry B, 2000, 104, 4080-4090). When the dopant ion is a drug, the storage and release of the drug can be realized by using this principle, so polypyrrole can be used as a carrier for drug release. At present, there have been reports on the controlled release of small molecules of polypyrrole glutamate, adenosine triphosphate (ATP), N-methylphenothiazine, naproxen, salicylate, fluorouracil (5-Fu), furfurouracil ( TF-207) and reports of a variety of drugs suc...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/48A61K31/60A61K47/30A61K47/58
Inventor 葛东涛戚汝财石巍黄三庆穆静张其清
Owner XIAMEN UNIV
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