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Composition for relieving exterior syndrome, clearing heat and detoxicating, method for preparing the same, and quality control method

A quality control method, heat-clearing and detoxifying technology, applied to medical preparations containing active ingredients, drug combinations, antipyretics, etc., can solve problems such as no therapeutic effect of antibiotics, exacerbation of the disease, and imbalance of normal flora

Active Publication Date: 2008-10-01
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In fact, many people now feel that taking a lot of antibiotics after a cold has no obvious effect. The main reason is that most colds are caused by viruses, and antibiotics have no therapeutic effect; The use of antibiotics is abused at will, and the result is not only no therapeutic effect, but also the emergence of a large number of drug-resistant strains (according to statistics, currently 80% of staphylococci are resistant to penicillin)
Moreover, the abuse of antibiotics can also cause the imbalance of normal flora in the body, making some non-pathogenic bacteria become pathogenic bacteria, thus making the condition worse

Method used

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  • Composition for relieving exterior syndrome, clearing heat and detoxicating, method for preparing the same, and quality control method
  • Composition for relieving exterior syndrome, clearing heat and detoxicating, method for preparing the same, and quality control method
  • Composition for relieving exterior syndrome, clearing heat and detoxicating, method for preparing the same, and quality control method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0079] Experimental Example 1 Pharmacological Test

[0080] Investigate the drug effect of the present invention, the following medicine group is made into granule by the method for embodiment:

[0081] Drug group I Patchouli 100g Chrysanthemum 130g Honeysuckle 110g Folium 130g Hedyotis diffusa 150g Rehmannia glutinosa 150g Moutan bark 150g Baiwei 130g Mint 70g Gypsum 90g Ophiopogon japonicus 70g

[0082] Drug group II Patchouli 120g Chrysanthemum 130g Forsythia 120g Folium Isatidis 90g Radix Radix 120g Dihuang 120g Digupi 130g Baiwei 130g Mint 65g Gypsum 100g

[0083] Drug group III Patchouli 75g Chrysanthemum 75g Forsythia 75g Folium Isatidis 125g Radix Radix 75g Dihuang 75g Digupi 75g Baiwei 75g Mint 50g Gypsum 125g

[0084] Positive control group Commercially available Ganmao Jiedu Granules

[0085] 1. The effect of dispelling wind and relieving exterior:

[0086] Get 40 rats with a body weight of 150~200g, half male and half male, randomly divided into four groups, wei...

experiment example 2

[0102] Experimental example 2 Identification method screening experiment

[0103] The quality control method of the Chinese medicine composition provided by the present invention is obtained after screening through a large number of specific creative tests, and some tests are now disclosed as follows:

[0104] (1) TLC identification of Daqingye

[0105] ① The investigation of the extraction time of the test solution

[0106] Get 30g of pharmaceutical granules of the present invention, grind finely, add 40ml of chloroform, extract by heating and reflux for 0.5h, 1.0h, 1.5h, let cool, filter, and the filtrate is concentrated to about 0.5ml, as the test solution. In addition, take indigo and indirubin reference substances, add chloroform to make a mixed solution containing 1mg per 1ml, as the reference substance solution. Compare and extract the expansion effect of need testing solution on the thin-layer plate at different times, and the results are shown in the following table...

experiment example 3

[0131] The mensuration of experimental example 3 n-butanol extracts

[0132] ①Dosage of n-butanol

[0133] Take an appropriate amount of the pharmaceutical granule of the present invention, grind it into powder, accurately weigh 2 g of the powder, put it in a conical flask, add 40, 50, and 60 ml of water-saturated n-butanol precisely, seal it tightly, weigh it, and leave it to stand for 1 hour , placed on a water bath and heated to reflux for 1 hour, allowed to cool, supplemented with n-butanol saturated with water to lose weight, shaken, filtered, and accurately measure 25ml of the subsequent filtrate, placed in an evaporating dish that had been dried to constant weight, evaporated to dryness, and placed at 105 Dry at ℃ for 3 hours, transfer to a desiccator, cool for 30 minutes, and weigh quickly and accurately. The results are shown in the table below:

[0134]

[0135] It can be seen from the above table that when the amount of n-butanol added is 50ml, the extract cont...

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Abstract

The invention discloses a pharmaceutical composition which has the effects of expelling wind, relieving the exterior, clearing heat and detoxifying, a preparation method and a quality control method thereof. The pharmaceutical composition of the invention consists of crude drugs as follows: patchouli, chrysanthemum, honeysuckle, dyer woad leaf, hedyotis diffusa, foxglove, tree peony bark, cynanchum atratum, mint and gypsum. The preparation method is characterized in that: water is added for decoction, the chrysanthemum, etc. is hot dipped, and the patchouli, the mint and water are used for extracting volatile oil which is condensed into clear paste. The pharmaceutical composition of the invention has good effects of expelling wind, relieving the exterior, clearing heat and detoxifying.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and quality control method, in particular to a traditional Chinese medicine composition with functions of dispelling wind, relieving exterior syndrome, clearing away heat and detoxification, and its preparation method and quality control method. Background technique [0002] Flu, commonly known as "cold", is a common respiratory disease caused by multiple viruses, 30%-50% of which is caused by a certain serotype of rhinovirus. Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonals is not just the same yet. The distribution of cold cases is sporadic, does not cause epidemics, and is often easily combined with bacterial infections. The onset of the common cold is rapid. Early symptoms include dry itching or burning sensation in the throat, sneezing, nasal congestio...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/16A61P31/14A61P31/16A61P11/02A61P11/04A61P11/14A61P29/00G01N30/90A61K33/06
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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