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Quality control method of cow-bezoar antiphlogistic tablet

A quality control method and technology for anti-inflammatory tablets, applied in the field of quality control of Niuhuang anti-inflammatory tablets, can solve problems such as failure to supervise drug safety and the like

Active Publication Date: 2008-08-27
杨文龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This standard only uses the microscopic identification method to control the internal quality of the traditional Chinese medicine. The current quality standard of Niuhuang Xiaoyan Tablets is difficult to identify because sometimes the microscopic characteristics of individual medicinal materials cannot be seen due to processing and other reasons. Make a non-compliance judgment, which fails to achieve the purpose of supervising drug safety

Method used

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  • Quality control method of cow-bezoar antiphlogistic tablet
  • Quality control method of cow-bezoar antiphlogistic tablet
  • Quality control method of cow-bezoar antiphlogistic tablet

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0021] Take 20 tablets of this product, remove the sugar coating, grind finely, add 40 ml of methanol, ultrasonically treat for 30 minutes, filter, and concentrate the filtrate to 5 ml as the test solution. Take another bile acid reference substance, add ethanol to make a solution containing 1 mg per 1 ml, as the reference substance solution. According to the test of thin-layer chromatography (Appendix VI B of the Chinese Pharmacopoeia in 2005), draw 10 microliters of each of the above two solutions, and place them on the same silica gel G thin-layer plate respectively, and use n-hexane-ethyl acetate-acetic acid-methanol -The upper layer solution of formic acid (20:25:2:3:0.1) is used as a developing agent, developed, taken out, dried, sprayed with 10% sulfuric acid ethanol solution, and heated at 105°C until the spots are clearly colored. In the chromatogram of the test product, there are spots of the same color at the position corresponding to the chromatogram of the referen...

experiment example 2

[0025] Take 15 tablets of this product, remove the sugar coating, grind finely, add 50 ml of chloroform, heat and reflux for extraction for 30 minutes, filter, and concentrate the filtrate to 1 ml as the test solution. Take another reference substance of indigo and indirubin, and add chloroform to make a mixed solution containing 1 mg per 1 ml, as the reference solution. According to the thin-layer chromatography (Appendix VI B of the Chinese Pharmacopoeia 2005 edition), draw 10 microliters of each of the above-mentioned three solutions, respectively spot on the same silica gel G thin-layer plate, and use chloroform-acetone (19:2) As a developing agent, unfold, take out, and let it dry. In the chromatogram of the test product, there are spots of the same color at the position corresponding to the chromatogram of the reference product.

[0026] Using this method to repeat the test of 10 batches of Niuhuang Xiaoyan Tablets, all were positive.

[0027]

experiment example 3

[0029] Take 20 tablets of this product, remove the sugar coating, grind finely, add 30 ml of methanol, heat and reflux for extraction for 30 minutes, let cool, filter, evaporate the filtrate to dryness, add 15 ml of water to dissolve the residue, add 1 ml of hydrochloric acid, and place in a hot water bath Heat for 30 minutes, cool immediately, extract twice with ether, 10 ml each time, combine the ether extracts, evaporate to dryness, add 1 ml of ethyl acetate to the residue to dissolve, and use it as the test solution. In addition, take chrysophanol and emodin reference substances, add methanol to make a mixed solution containing 1 mg in each 1 ml, as the reference solution. According to the thin-layer chromatography (Appendix VI B of the Chinese Pharmacopoeia in 2005 edition), each 5 microliters of the above-mentioned two solutions were drawn, and they were respectively spotted on the same silica gel G thin-layer plate with carboxymethylcellulose sodium as the binding agent....

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Abstract

The invention relates to a bezoar antiphlogistic tablet, which is a Chinese herbal medicine compound preparation composed of seven traditional Chinese medicines, namely bezoar, mother-of-pearl, senso, natural Indigo, trichosanthin, rhubarb and realgar, and has the efficacies of heat-clearing and detoxifying and detumescence analgesic. The tablet is used for treating various symptoms such as swollen sore throat, boil, carbuncle, and scabies; the bezoar antiphlogistic tablet has the advantages of small taking dose, definite curative effect, etc. However, because the preparation has more animal drugs and toxic drugs, the clinical use is very cautious, and the quality standard of the actual bezoar antiphlogistic tablet cannot completely achieve the purpose of supervising drug safety yet. The bezoar antiphlogistic tablet aims to provide a more perfect quality control method on chemical makeup establishing and ration.

Description

【Technical field】 [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a quality control method of Niuhuang Xiaoyan Tablets. 【Background technique】 [0002] Niuhuang Xiaoyan Tablet is a traditional Chinese medicine compound preparation composed of 7 traditional Chinese medicines such as Niuhuang and Toad Su. Certain advantages such as curative effect. [0003] The prescription of Niuhuang Xiaoyan Tablets is: Niuhuang 4.8g, mother-of-pearl 9.6g, toad venom 2.9g, Qingdai 3.8g, trichosanthin 9.6g, rhubarb 9.6g, realgar 9.6g. [0004] The specific preparation method of Niuhuang Xiaoyan Tablets is as follows: the above seven flavors, realgar and mother-of-pearl are watered or crushed into fine powder; rhubarb and trichosanthum powder are crushed into fine powder; Mix in an appropriate amount, make granules, and dry; Grind Calculus Bezoar finely, add to the above granules, mix evenly, press into 1000 tablets, coat wit...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/28A61P11/04A61P17/02G01N30/02G01N30/36G01N30/90A61K33/36A61K35/413A61K35/56
Inventor 杨文龙
Owner 杨文龙
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