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Polyene phosphatidylcholine high-capacity injection

A technology of polyene phosphatidylcholine and injection, which is applied in the digestive system, organic active ingredients, diseases, etc., can solve the problems of environment, equipment pollution, cumbersome procedures, and endangering the lives of patients, so as to avoid cross-infection, The effect of reducing the dilution process and improving the level of clinical application and safety

Inactive Publication Date: 2008-08-20
桂勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the mixing of liquid before intravenous injection, some disadvantages have been brought about. Not only is the procedure cumbersome, but it is also easily polluted by the environment and equipment, causing patients to have infusion reactions, such as fever, nausea, chills, rapid or slow heartbeat, etc. In severe cases, it can endanger the patient's life

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Example 1: Preparation of Polyene Phosphatidyl Chole Glucose Injection

[0020] prescription:

[0021] Polyene Phosphatidylchole (Soy Lecithin) 4.65g

[0022] Deoxycholic acid 3.88g

[0023] Sodium hydroxide 0.388g

[0024] Vitamin E 0.2g

[0025] Absolute ethanol 5.47ml

[0026] Riboflavin 0.01g

[0027] Glucose 50g

[0028] Add water for injection to 1000ml

[0029] Preparation

[0030] (1) Preparation of isotonic agent concentrated solution

[0031] Take 50g of glucose, add 150ml of water for injection, stir to dissolve, add 0.3% activated carbon and boil for 15 minutes, filter through a sand filter to decarbonize, add water to 800ml, filter through a 0.22 μm microporous membrane to obtain a concentrated solution of isotonic agent.

[0032] (2) Preparation of concentrated solution of polyene phosphatidylcholine

[0033] 1. Take 5.47ml of absolute ethanol, add 4.65g of polyene phosphatidylcholine (or soybean lecithin), 0.2g of vitamin E, stir to dissolve;

...

example 2

[0038] Example 2: Preparation of Polyene Phosphatidyl Chole Glucose Injection

[0039] prescription:

[0040] Polyene Phosphatidylcholine (Soy Lecithin) 9.3g

[0041] Deoxycholic acid 7.76g

[0042] Sodium hydroxide 0.776g

[0043] Vitamin E 0.4g

[0044] Absolute ethanol 10.94ml

[0045] Riboflavin 0.02g

[0046] Glucose 50g

[0047] Add water for injection to 1000ml

[0048] Preparation

[0049] (1) Preparation of isotonic agent concentrated solution

[0050] Take 50g of glucose, add 150ml of water for injection, stir to dissolve, add 0.3% activated carbon and boil for 15 minutes, filter through a sand filter to decarbonize, add water to 800ml, filter through a 0.22 μm microporous membrane to obtain a concentrated solution of isotonic agent.

[0051] (2) Preparation of concentrated solution of polyene phosphatidylcholine

[0052] 1. Take 10.94ml of absolute ethanol, add 9.3g of polyene phosphatidylcholine (or soybean lecithin), 0.4g of vitamin E, stir to dissolve; ...

example 3

[0057] Example 3: Preparation of Polyene Phosphatidyl Chole Glucose Injection

[0058] prescription:

[0059] Polyene Phosphatidylchole (Soy Lecithin) 0.465g

[0060]Deoxycholic acid 0.388g

[0061] Sodium hydroxide 0.039g

[0062] Vitamin E 0.02g

[0063] Absolute ethanol 0.547ml

[0064] Riboflavin 0.001g

[0065] Glucose 50g

[0066] Add water for injection to 1000ml

[0067] Preparation

[0068] (1) Preparation of isotonic agent concentrated solution

[0069] Take 50g of glucose, add 150ml of water for injection, stir to dissolve, add 0.3% activated carbon and boil for 15 minutes, filter through a sand filter to decarbonize, add water to 800ml, filter through a 0.22 μm microporous membrane to obtain a concentrated solution of isotonic agent.

[0070] (2) Preparation of concentrated solution of polyene phosphatidylcholine

[0071] 1. Take 0.547ml of absolute ethanol, add 0.465g of polyene phosphatidylcholine (soybean lecithin), 0.02g of vitamin E, and stir to diss...

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PUM

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Abstract

The invention discloses a polyene phosphatidylcholine large volume injection which is prepared by the mixture of polyene phosphatidylcholine or soybean phospholipid as the active component and the pharmaceutical carrier; the content proportion of the active component in the injection is 0.0465% to 0.93%. The invention is characterized in that the polyene phosphatidylcholine injection can be used to intravenous infusion directly. The polyene phosphatidylcholine large volume injection has the advantage that the diluting process in the present medication condition is omitted; cross infection is avoided; the clinical application level and safety is improved; and the convenient use is guaranteed.

Description

technical field [0001] The invention relates to a large volume injection of polyene phosphatidylcholine. Background technique [0002] Polyene phosphatidylcholine is a commonly used digestive system drug at home and abroad. The State Drug Administration standard "Polyene Phosphatidylcholine Injection" indicates that it is a drug for the treatment of liver and gallbladder diseases. For various types of liver diseases, such as hepatitis, chronic hepatitis, liver necrosis, liver cirrhosis, hepatic coma (including prodromal coma), fatty liver, biliary obstruction, poisoning, prevention of recurrence of gallstones, treatment before and after surgery, especially hepatobiliary Surgery, pregnancy poisoning, psoriasis, neurodermatitis, radiation syndrome. Intravenous injection or intravenous drip can also be used after diluting with glucose injection without electrolytes during intravenous drip. Due to the mixing of liquid before intravenous injection, some disadvantages have been...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/6615A61P1/16A61P31/14A61P31/20A61P15/00A61P17/06A61P17/00A61P43/00
Inventor 桂勇袁振
Owner 桂勇
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