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Long chain fatty milk in camelina sativa oil orally-administered or injection preparations

A technology for injection preparations and camellia oil, which is applied in the direction of oil/fat/wax non-active ingredients, emulsion delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of undisclosed technical solutions and improve immune function , reduce adverse reactions, increase the effect of levels

Inactive Publication Date: 2008-06-04
范旻
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] Thus it can be seen that the application of catkinsia indigo oil in fat emulsion has practical significance, but there is no disclosure of relevant technical solutions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, the oral or injectable preparation of this fat emulsion is composed of medicinal vegetable oil camelina oil, medium chain fatty acid glycerides (MCT) as fast energizer, lecithin as emulsifier, refined oil as oily solvent, etc. The osmotic regulator is formulated with glycerin and purified water / water for injection, and its dosage prescription:

[0035] camelina oil 1g

[0036] MCT 20g

[0037] Sunflower Oil 99g

[0038] Lecithin 10g

[0039] Glycerin 22g

[0040] Purified water / water for injection add to 1000g

[0041] That is, its dosage-to-weight ratio is:

[0042] Camelina oil 0.1%

[0043] MCT 2%

[0044] Sunflower Oil 9.9%

[0045] Lecithin 1%

[0046] Glycerin 0.22%

[0047] Purified water / water for injection 86.78%

[0048] Take 1.0 g of camelina oil, 20 g of MCT, 99 g of sunflower oil, and 12 g of lecithin, stir for about 10 minutes and mix well, and take another 800 g of purified water / water for injection, and add 22 g of glycerol. Und...

Embodiment 2

[0049] Embodiment 2, camelina oil fat emulsion oral or injection preparation (20%, weight content) prescription:

[0050] Camelina Oil 200g

[0051] MCT 10g

[0052] Sunflower Oil 99g

[0053] Lecithin 12g

[0054] Glycerin 22g

[0055] Purified water / water for injection add to 1000g

[0056] That is, its dosage-to-weight ratio is:

[0057] Camelina oil 20%

[0058] MCT 1%

[0059] Sunflower Oil 9.9%

[0060] Lecithin 1.2%

[0061] Glycerin 0.22%

[0062] Purified water / water for injection 67.68%

[0063] Take 200 g of camelina oil, add 12 g of lecithin and 10 g of MCT, stir for about 10 minutes and mix well, take another 800 g of purified water / water for injection, and add 22 g of glycerol. Under nitrogen protection, the phospholipid oil solution was added to the aqueous glycerol solution to adjust the total amount to 1000 g. Homogenize 7-8 times by a high pressure homogenizer, the pressure is 100Mpa, until the particle size is in the range of 180-300nm, adjust th...

Embodiment 3

[0064] Example 3: In Examples 1 and 2, medium chain fatty acid glycerides (MCT) are used as fast energy-supplying agents, and the lecithins used as emulsifiers are egg yolk lecithin, soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated Any of soybean lecithin and synthetic lecithin. The refined oil used as the oily solvent is any one of refined soybean oil, refined corn oil, refined sunflower oil, refined peanut oil, refined sesame oil, refined rapeseed oil, and refined olive oil. The entire production process is carried out under nitrogen protection.

[0065] Take the medicinal vegetable oil, MCT, and sunflower oil in the prescribed amount, add lecithin, heat and stir for 10 minutes to dissolve it completely. Take another purified water / water for injection and add glycerol. Under nitrogen protection, slowly add the phospholipid oil solution to the glycerol aqueous solution stirred at high speed (3000 r / min) with a shearing machine, and continue stirring for 30 min...

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Abstract

An oral or injection preparation of the medium and long-chain fat emulsion of Camelina sativa oil relates to a medical care and nutritional fat emulsion product which contains Camelina sativa oil and is prepared according to prescription. The weight proportion of the invention is: 0.1 percent to 20 percent of Camelina sativa oil which is taken as medicine, 0 percent to 20 percent of MCT which is taken as rapid energy-provision agent, 0 percent and 15 percent of lecithin which is taken as emulsifier, 0 percent and 30 percent of refined oil which is taken as oil solvent and 0.15 to 0.25 percent of glycerin which is taken as isoosmotic adjustment agent, and water for injection is added till the total amount reaches 1000g; wherein, the final osmotic pressure of glycerin which is taken as isoosmotic adjustment agent is 0.5 to 3 isotonic concentration. The invention has the advantages that the preparation not only satisfies the fundamental needs of the human body on essential fatty acid, but also can greatly reduce the adverse effects caused by excessive polyunsaturated fatty acid and saturated fatty acid simultaneously. Compared with the common soybean oil fat emulsion, the invention can reduce lipid peroxidation to the utmost degree, improve immunity, increase the level of the active vitamin E Alpha-tocopherol in the human body, enhance the stability of the emulsion and speed up the synthesis of long-chain fatty acids.

Description

1. Technical field: [0001] The invention relates to a formula-prepared fat emulsion for medical and health care nutritional products containing camelina oil, in particular to an oral or injection preparation of a long-chain fat emulsion in camelina oil. 2. Background technology: [0002] Fat emulsion is an important part of clinical nutrition, it must provide essential and non-essential fatty acids in addition to providing energy. Fatty acids are an important source of lipids that maintain cellular integrity and maintain cellular function. It is also a precursor of biologically active lipid mediators, and it also has the functions of regulating enzyme activity, ion channels and gene expression. The fatty acids in parenteral nutrition are provided in the form of emulsions of various natural oils, such as soybean oil, palm oil, olive oil, etc. All kinds of oils contain a component of lipid, which determines the biological activity of this type of fat emulsion. [0003] Exis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61K9/107A61K47/44A61K47/24A61K47/14A61K47/10A61P3/02
Inventor 范旻任远东于涌
Owner 范旻
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