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Complex self-curing material, method and application of bioactivity calcium phosphate/tricalcium silicate

A tricalcium silicate, bioactive technology, applied in chemical instruments and methods, physical/chemical process catalysts, chemical/physical processes, etc., can solve the problem of poor bone-like apatite deposition ability, bonding strength and osteoconductivity strength. Poor, low strength and other problems, to achieve the effect of excellent biocompatibility, excellent biological activity

Inactive Publication Date: 2010-05-19
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the application of this material, which are mainly reflected in the following aspects: First, although this type of calcium phosphate bone cement solidifies quickly, its strength is very low after solidification, so it can only be used for non-load-bearing ( non-load beared) bone defect repair; secondly, this material is similar to calcium phosphate ceramics, and has poor ability to induce bone-like apatite deposition, and new tissue can only crawl along the CPC surface or internal microporous surface for replacement. Poor bone conduction strength

Method used

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  • Complex self-curing material, method and application of bioactivity calcium phosphate/tricalcium silicate
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  • Complex self-curing material, method and application of bioactivity calcium phosphate/tricalcium silicate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1) Blending liquid preparation

[0052] Weigh 2.0 g of analytically pure sodium pyrophosphate and dissolve it in 98.0 mL of deionized water to obtain a 2.0% sodium pyrophosphate solution, sterilize, seal it in a sterile bottle, and set aside.

[0053] 2) Preparation of calcium phosphate / tricalcium silicate composite bone defect filling material:

[0054] The calcium phosphate / tricalcium silicate composite material powder with a tricalcium silicate content of 20wt.% and the blending solution are fully blended at a liquid-solid mass ratio of 0.5:1 for 0.5-1 minute, injected into the mold, and heated at 37°C and After curing for more than 24 hours under 100% humidity, the calcium phosphate / tricalcium silicate composite pellets (CPC / C 3 S Pellets). The compressive strength of the pellets can reach 14.0∽19.0 MPa, the degradation rate can reach about 15% after 21 days, and it has good biological activity.

Embodiment 2

[0056] 1) Blending liquid preparation

[0057] Weigh 2.0 g of analytically pure sodium pyrophosphate and dissolve it in 98.0 mL of deionized water to obtain a 2.0% sodium pyrophosphate solution, sterilize, seal it in a sterile bottle, and set aside.

[0058] 2) Preparation of calcium phosphate / tricalcium silicate composite self-curing material:

[0059] The calcium phosphate / tricalcium silicate composite material powder with a tricalcium silicate content of 30wt.% and the blending solution are fully blended at a ratio of liquid-solid mass ratio of 0.5:1 for 0.5-1 minute, which can be used for minimally invasive treatment. Calcium phosphate / tricalcium silicate composite self-curing material. The self-curing material can be solidified in about 15 minutes after being injected into the defect, and the self-curing material slurry can be completely injected within 5 minutes. The compressive strength of the self-curing material can reach 36.0∽40.0MPa, and the degradation rate is abo...

Embodiment 3

[0061] Preparation of concoction

[0062] The simulated body fluid is used as the blending solution, and the ion concentration of the simulated body fluid is as follows (pH=7.25-7.4):

[0063] Table 2 Ionic composition of simulated body fluid

[0064] Ion species

Na +

K +

Mg 2+

Ca 2+

Cl -

HCO 3 -

HPO 4 2-

ion concentration

(mmol / L)

142.0

5.0

1.5

2.5

148.8

4.2

1.0

[0065] Preparation of calcium phosphate / tricalcium silicate composite degradable materials

[0066] The calcium phosphate / tricalcium silicate composite material powder with a tricalcium silicate content of 1-50wt.% and the blending solution are fully blended at a liquid-solid mass ratio of 0.5-1.0:1 for 0.5-1 minute, and injected into the mold. Cured at 37°C and 100% humidity for more than 24 hours, after which the calcium phosphate / tricalcium silicate composite pellets (CP / C)...

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Abstract

The invention relates to human bone defect filling original position self-solidified bioactive material and the preparation method thereof. The material is bone / tooth defect repair material which is developed with bioactive calcium phosphate / tricalcium silicate composite powder and mixing liquid having the biological activity as raw materials. Compared with the prior material, the material of theinvention has the advantages that the biological activity is excellent, the shaping is arbitrary, the material is self-solidified, no cytotoxicity exists, and the degradation is gradual, the degradation rate can be adjusted, and the effect of inducing bone-like apatite formation can be achieved; the biological activity is more excellent than that of the calcium phosphate calcium phosphate bone-like cement, and the preparation method is simple.

Description

technical field [0001] The invention relates to a bioactive calcium phosphate / tricalcium silicate composite self-curing material, a preparation method and an application. The provided material is used as a filling and repairing material for human hard tissue defects, that is, as a bioactive material for filling and repairing human bone and tooth defects. , for use in orthopedics, dentistry and minimally invasive treatments. It belongs to the field of medical biomaterials. Background technique [0002] In the mid-1980s, Brown and Chow invented a new type of self-curing bioactive bone repair material - calcium phosphate cement (Calcium Phosphate Cement; CPC). CPC refers to a calcium phosphate (Calcium Phosphate, CP) material that is mixed with several phosphate powders and a blending solution, undergoes a hydration reaction at room temperature or the temperature of the human body, and can spontaneously solidify. CPC is different from ceramic materials. Its preparation, moldi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J27/12
Inventor 常江郇志广
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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