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Domperidone orally disintegrating tablets and method for preparing the same

The technology of oral disintegrating tablet and domperidone is applied in the field of domperidone oral disintegrating tablet and its preparation, which can solve the problems of drug precipitation, affecting drug absorption, inconvenient taking of ordinary tablets, etc., achieving less intestinal residue and solving difficulty in taking medicine , the effect of improving medication adherence

Inactive Publication Date: 2008-04-02
上海爱的发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are ordinary tablets and suspensions of domperidone, but these concentrated preparations have defects in varying degrees. The ordinary tablets are not convenient enough to take, and drug precipitation will occur in the suspension when stored for a long time, which will affect the absorption of the drug. There are obvious deficiencies in the dosage forms above, and there is an urgent need to develop new oral preparations with better effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Domperidone 50g

[0029] Mannitol 700g

[0030] Cross-linked polyvinylpyrrolidone 80g

[0031] Aspartame 15g

[0032] Orange essence 7.5g

[0033] Peppermint essence 7.5g

[0034] Silica 7.5g

[0035] Magnesium Stearate 15g

[0036] Mix the domperidone raw material and part of mannitol on the principle of equal increase, sieve through 20 mesh twice, then pour into a three-dimensional mixer and mix for 15 minutes; mix silicon dioxide, aspartame, orange essence, mint essence, Mix the cross-linked polyvinylpyrrolidone and the remaining mannitol, sieve through 20 meshes, pour into the three-dimensional mixer and mix with the mixed powder in the previous step for 30 minutes; add magnesium stearate and mix for 1-2 minutes; pour the mixed material Put it into the hopper of the tablet press, adjust the weight and pressure of the tablet, press the tablet and keep the hardness of the tablet at 20-40N; double-aluminum cold-formed blister packaging.

Embodiment 2

[0038] Domperidone 50g

[0039] Mannitol 950g

[0040] Cross-linked polyvinylpyrrolidone 100g

[0041] Aspartame 20g

[0042] Orange essence 9g

[0043] Peppermint essence 9g

[0044] Silica 9g

[0045] Magnesium Stearate 15g

[0046] Mix the domperidone raw material and part of mannitol on the principle of equal increase, sieve through 20 mesh twice, then pour into a three-dimensional mixer and mix for 15 minutes; mix silicon dioxide, aspartame, orange essence, mint essence, Mix the cross-linked polyvinylpyrrolidone and the remaining mannitol, sieve through 20 meshes, pour into the three-dimensional mixer and mix with the mixed powder in the previous step for 30 minutes; add magnesium stearate and mix for 1-2 minutes; pour the mixed material Put it into the hopper of the tablet press, adjust the weight and pressure of the tablet, press the tablet and keep the hardness of the tablet at 20-40N; double-aluminum cold-formed blister packaging.

Embodiment 3

[0048] Domperidone 50g

[0049] Mannitol 550g

[0050] Cross-linked polyvinylpyrrolidone 60g

[0051] Aspartame 10g

[0052] Orange essence 5g

[0053] Peppermint essence 5g

[0054] Silica 5g

[0055] Magnesium Stearate 7.5g

[0056] Mix the domperidone raw material and part of mannitol on the principle of equal increase, sieve through 20 mesh twice, then pour into a three-dimensional mixer and mix for 15 minutes; mix silicon dioxide, aspartame, orange essence, mint essence, Mix the cross-linked polyvinylpyrrolidone and the remaining mannitol, sieve through 20 meshes, pour into the three-dimensional mixer and mix with the mixed powder in the previous step for 30 minutes; add magnesium stearate and mix for 1-2 minutes; pour the mixed material Put it into the hopper of the tablet press, adjust the weight and pressure of the tablet, press the tablet and keep the hardness of the tablet at 20-40N; double-aluminum cold-formed blister packaging.

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Abstract

The invention discloses a domperidone orally disintergrating tablet and the preparation method. The domperidone orally disintergrating tablet of the invention contains effective dose of domperidone and pharmaceutical excipient which is capable of rapidly disintegrating and releasing medicine in the oral cavity. The preparation method adopts modern preparation technology and the product has stable quality. So the preparation method provides patients with a safe and effective domperidone orally disintergrating tablet which is absorbed rapidly.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a domperidone orally disintegrating tablet prepared by modern tablet technology and a preparation method thereof. Background technique [0002] Domperidone is a drug for digestive system diseases developed by Janssen Pharmaceutical Company of Belgium. This product is a peripheral dopamine receptor antagonist with strong effect, acts directly on the gastrointestinal wall, can moderately increase the tension of the lower esophageal sphincter, prevent gastroesophageal reflux; enhance tail peristalsis, promote gastric emptying, Improve the motility coordination of stomach and duodenum, prevent bile reflux, regulate and restore the motility of upper gastrointestinal tract; inhibit nausea and vomiting. Does not affect gastric acid secretion. Rapidly absorbed after oral administration. [0003] According to literature reports, domperidone is not only used for chronic gastri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/454A61P1/04A61P1/14A61P1/16
Inventor 胡愈璋陈敏娟徐景朱雨秋
Owner 上海爱的发制药有限公司
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