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Method for preparing high-purity arabinogalactan

A technology for arabinogalactan and an adsorbent, which is applied in the field of membrane separation technology for preparing high-purity arabinogalactan, can solve the problems of complicated regeneration and utilization, time-consuming, high purification cost, and saves production time and cost. The effect of eliminating column packing and improving yield

Inactive Publication Date: 2008-03-19
NORTHEAST FORESTRY UNIVERSITY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the operation of column packing, washing and adsorbent regeneration is complicated, time-consuming, and the purification cost is high

Method used

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  • Method for preparing high-purity arabinogalactan

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] Put 600 g of crushed Xing’an larch shavings with a particle size of 20 mesh or more into an ultrasonic extraction tank, add 30 L of water solvent at 50 °C, seal the extraction tank, set the extraction process temperature to 60 °C, time 60 min, and ultrasonic output frequency to 47 kHz. After the material is subjected to ultrasonic cavitation in the extraction tank, the ultrasonic generator is turned off, and the 80um modified fiber bundle membrane filter device is used to filter to obtain the crude extract A of arabinogalactan, and the solution is yellowish brown. In the crude Arabinogalactan extract A, according to the ratio of 22.32g / L, pretreated KH-862 medical activated carbon-assisted microfiltration clarification system was added for decolorization and purification to obtain filtrate B. Take 20L of filtrate B and concentrate it through a cellulose membrane with a cut-off molecular weight of 5000Da. During ultrafiltration, the inlet pressure was 0.6 MPa, the feedin...

example 2

[0023] Put 600 g of Xing’an larch wood powder with a particle size of 20-60 mesh into an ultrasonic extraction tank, add 30 L of water solvent at 35 °C, seal the extraction tank, set the extraction process temperature to 42 °C, time 150 min, and ultrasonic output frequency to 70 kHz. After the material is subjected to ultrasonic cavitation in the extraction tank, the ultrasonic generator is turned off to obtain the crude extract A of arabinogalactan. According to the ratio of 20.82g / L, add the pretreated KH-762 medical active carbon assisted microfiltration clarification system to the crude extract A for decolorization and purification, and the remaining operating parameters are the same as in Example 1. After the purified liquid D was dried, a beige powdery arabinogalactan was obtained, with a yield of 9.21% and a purity of 92.3% relative to the raw material (dry wood powder).

example 3

[0025] Put 600g of Xing’an larch wood powder with a particle size of 20-60 mesh into the extraction tank, add 30L of water solvent at 42°C, set the extraction process temperature at 60°C, time 60min, and ultrasonic output frequency at 67.8kHz. After the material is subjected to ultrasonic cavitation in the extraction tank, the ultrasonic generator is turned off to obtain the crude extract A of arabinogalactan. According to the ratio of 40.17g / L, a pretreated 100-200 mesh diatomaceous earth-assisted microfiltration clarification system was added to the crude extract A for decolorization and purification, and the rest of the operation process was the same as in Example 1. After freeze-drying the purified solution D, arabinogalactan was obtained in the form of yellow powder, with a yield of 12.91% and a purity of 82.7% relative to the raw material (dry wood powder).

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Abstract

The invention discloses a technique which prepares high-purity arabogalactan from a dahuricia larch. The arabogalactan has effects of obvious increase of boy immunity, tumor resistance, mutation resistance, reduction of blood lipid, virus resistance and enhancement of the immunoreactive activity of monocytes, macrophages, T cells and natural killer cells in immune antigens. The preparation technique includes ultrasonic-assisted extraction, ultrafiltration concentration, washing purification and drying. The preprocessed dahuricia larch as a material is mixed with a designated solvent, extraction process is fulfilled in the energy field of ultrasonic energy, so that the crude extractant A of the arabogalactan is produced. The invention applies adsorbent to absorb the non-saccharide ingredients in the crude extractant A, and applies membrane separation techniques, such as microfiltration, ultrafiltration, etc., to separate arabogalactan, and after removing impurities in the crude extractant, small-molecule pigments and partial solvent, the purified arabogalactan solution D. The purified arabogalactan solution D is refrigerated and dried in order to obtain the white or light yellow powdery high-purity arabogalactan, and purity can reach over ninety five percent.

Description

technical field [0001] The invention discloses a method for preparing high-purity Arabinogalactan (Arabinogalactan, abbreviated as AG) by membrane separation technology. Background technique [0002] a. The research background of the preparation technology of high-purity arabinogalactan [0003] Arabinogalactan can significantly improve the body's immunity, enhance the immune response activity of monocytes, macrophages, T cells and natural killer cells in immune antigens, and produce non-specific cell killing effects, and can induce endogenous Derived interferon, LAK cells and tumor necrosis factor, etc. As the main component in combination with other drugs, it can be used to control the treatment of pleural effusion, ascites, lung cancer, liver cancer, esophageal cancer, bladder cancer, malignant lymphoma, advanced gastric cancer and melanoma caused by various tumors, and significantly prolong the survival period of cancer patients. . In addition, the concentration of ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
Inventor 方桂珍马艳丽任世学
Owner NORTHEAST FORESTRY UNIVERSITY
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