Hydrogenated castor oil nano-lipophilic medicine preparation and preparation method thereof

A technology of hydrogenated castor oil and pharmaceutical preparations, which can be used in pharmaceutical formulations, oil/fat/wax non-active ingredients, liposome delivery, etc. It can solve the problems of ineffective drug efficacy, poor drug dispersion, and low availability and other problems, to achieve the effect of convenient administration route, low cost, and improved dispersion

Inactive Publication Date: 2008-03-19
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, many lipophilic drugs (such as praziquantel, abamectin, etc.) lack suitable preparations, and the dispersion of the drug after administration is poor, and the utilization is low, so the drug effect cannot be effectively exerted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mix 5 mg of praziquantel with 95 mg of hydrogenated castor oil, add 100 ul of absolute ethanol and heat to 95 ° C to dissolve, then add the mixed solution to a stirring state (100 rpm) at a concentration of 0.5% (w / v), In 4 ml of polyvinyl alcohol aqueous solution at 95° C., and then treated with ultrasonic waves at 1 watt for 1 minute to form a nanoemulsion. After the emulsion was cooled below 90°C, 1 volume of water was added, and the nanoparticles were collected by centrifugation at 10,000g for 30 minutes. Each 100 mg of nanoparticles was suspended in 5 ml of pure water by shaking, and freeze-dried into a powder.

[0032] The average particle diameter of the tested preparation is 96 nanometers, and the drug loading is 4.5% (w / w).

Embodiment 2

[0034] Mix 250mg of praziquantel with 750mg of hydrogenated castor oil, add 1ml of absolute ethanol and heat to 95°C to dissolve, then add the mixture to a stirring state (1000 rpm), concentration of 1%, temperature at 98°C 60ml of polyvinyl alcohol aqueous solution, and then treated with ultrasonic waves at a power of 100 watts for 15 minutes to form a nanoemulsion. After the emulsion was cooled below 90°C, 3 times the volume of water was added, and the nanoparticles were collected by centrifugation at 10,000 g for 60 minutes. Each 100 mg of nanoparticles was suspended in 10 ml of pure water by pipetting, and freeze-dried into a powder.

[0035] The average particle diameter of the tested preparation is 115 nanometers, and the drug loading is 22% (w / w).

Embodiment 3

[0037] Mix 5 g of praziquantel with 5 g of hydrogenated castor oil, add 10 ml of absolute ethanol and heat to 100° C. 1 liter of polyvinyl alcohol aqueous solution, and then treated with ultrasonic wave at a power of 500 watts for 30 minutes to form a nanoemulsion. After the emulsion was cooled below 90°C, 5 times the volume of water was added, and the nanoparticles were collected by centrifugation at 10,000 g for 90 minutes. Each 100 mg of nanoparticles was suspended in 10 ml of pure water by shaking, and freeze-dried into a powder.

[0038] The average particle diameter of the tested preparation is 145 nanometers, and the drug loading is 45% (w / w).

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PUM

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Abstract

The invention provides a nanometer-lipophilic drug preparation of hydrogenated castor oil and the preparation method of the nanometer-lipophilic drug preparation. The nanometer drug preparation consists of a lipophilic drug, the hydrogenated castor oil and little polyvinyl alcohol. The nanometer-lipophilic drug preparation of hydrogenated castor oil of the invention has the efficacy of slowly releasing and at the same time is capable of improving the dispersion of the drug, the utilization degree of the drug and the drug effect, and that the storage, the transportation and the administration route of the drug are more convenient.

Description

technical field [0001] The invention relates to a nano-lipophilic pharmaceutical preparation of hydrogenated castor oil and a preparation method thereof, belonging to the field of nano-biotechnology. Background technique [0002] Solid lipid nanoparticles are a new type of nanoparticle drug delivery system being developed in recent years. They use natural or synthetic solid lipids (such as lecithin, triphthalglycerin, etc.) Form a solid micelle drug delivery system with a particle size of about 50-1000 nm. Its advantages are good physiological compatibility, controllable drug release, and good targeting; it not only has the advantages of high stability of polymer nanoparticles and slow drug leakage, but also has the low toxicity of liposomes , The advantages of low cost and large-scale production. [0003] Hydrogenated castor oil is a solid triglyceride formed by hydrogenation of ricinoleic acid, the main component of castor oil. It is cheap, biodegradable in the body, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44A61K9/127A61K9/14A61K31/4985A61K31/7048
Inventor 周文忠汪明于咏兰
Owner CHINA AGRI UNIV
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