Diacetyl morphine quick-speed testing apparatus

Abstract

The invention comprises: carrier, sampling pad, reaction block, peridium film and absorbent paper. Said sampling pad, reaction block, peridium film and absorbent paper are sequentially pasted on the carrier; said reaction block containing the antigen and antibody to the 6-acetyl morphin which is a specificity metabolite of heroin; the antigen to the 6-acetyl morphin has B,C two structures; the B is 6 bits and is connected to the bovine serum albumin; the C is connected to the bovine serum albumin through N base group.

Description

technical field [0001] The invention relates to a device for rapidly detecting heroin in human body fluid. Background technique [0002] Heroin is a world-recognized drug, which is extremely harmful to human beings. Heroin smoking is one of the daily targets of the public security traffic police in our country. The detection and analysis method is used to judge, not only the detection time is long, the detection is very inconvenient, and the work efficiency is extremely low, but also the traditional gas phase or liquid chromatography can not implement rapid detection and discrimination on the spot. In the patent 200510038688. and drug devices, which are based on morphine-specific antigens or antibodies. Although some drug addicts can be detected with this product, there are both a high proportion of false positives and a certain proportion of drug users in the test results. False negatives, this problem has plagued the daily law enforcement of law enforcement officers. The...

AI Technical Summary

Problems solved by technology

When people inhale prescription analgesics such as codeine (Codeine, structural formula is E), morphine will also be produced in body fluids; on the other hand, many prescription analgesics contain substances similar to morphine ( Such as Hydrocodone, the structural formula is F; Hydromorphone, the structural formula is G; Oxymorphone, the structural formula is H; Oxycodone, the structural formula is I), even if these items do not produce morphine during human metabolism, false positive results will also be produced, that is, when the human body fluid is stored When there are such groups, the morphine reagent will also be positive. Therefore, there are technically insurmountable defects in the detection of heroin with existing products.

According to the U.S. "JOURNAL OFANALYTICAL TOXICOLOGY" VOL30, March 2006, pages 73-79, 3521 urine samples (707 of which were provided by drug addicts) were detected and compared with the immunoassay based on the development of morphine antibody and chromatographic mass spectrometry, among which Immunoassay test results: 797 showed positive results, accounting for 22.6%. Of the 707 urine samples provided by drug addicts, 306 showed positive results, accounting for 43.3%. 9.1%, 169 accounted for 23.9%, so there is a large proportion of false positives in the detection of immunoassays based on the development of morphine antibodies, and the accuracy is not high

Also pointed out in this report, the morphine concentration in the urine of about 10% of the heroin inhalers is lower than 300ng / ml, then shows as negative with existing method test, and this is so-called false negative; Antibody-developed immunoassay to detect heroin inaccurate

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