Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Type A inactivated vaccine for hoof-and-mouth disease

A technology for inactivated vaccines and foot-and-mouth disease, which is applied in the direction of antibody medical ingredients, medical preparations containing active ingredients, antiviral agents, etc., to achieve the effects of optimizing production technology, good immunogenicity, and reducing side effects

Active Publication Date: 2010-06-30
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the fact that there is no commercialized safe and efficient type A foot-and-mouth disease inactivated vaccine in China, it is extremely urgent to develop a type A foot-and-mouth disease inactivated vaccine, which has important strategic significance for preventing the invasion of foreign foot-and-mouth disease virus

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A kind of foot-and-mouth disease A type inactivated vaccine, by inactivated A type foot-and-mouth disease virus antigen AF / 72 (accounting for 50% of vaccine total amount) and adjuvant (Montanide ISA206 adjuvant (montanide 206) that French SEPPIC company produces , formed by autoclaving, accounting for 50% of the total amount of the vaccine) jointly prepared by the following process methods and sequences.

[0038] 1 Virus species: AF / 72, a type A foot-and-mouth disease bovine tongue skin virus isolated in 1972, identified, preserved and supplied by the National Foot-and-Mouth Disease Reference Laboratory of Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. After the virus seed was diluted 1:10000 times, inoculated cattle without FMD A serum antibody had typical FMD vesicle lesions in 4 hooves within 48 hours, half the infectious dose (ID 50 / 0.1mL) is 10 -8.00 ; Dilute the bovine tongue skin virus 1:10 and inoculate 2-3 day-old suckling mi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a foot-and-mouth disease A-typed inactivated vaccine, which comprises the following steps: setting the rate of A-typed foot-and-mouth disease antigen and antigen at 1: 1; growing virus; breeding; inactivating; detecting; dispensing; detecting the vaccine. The evenly immune effect of A-typed foot-and-mouth disease is 7. 27PD50 / head to exceed the standard of international strategic emergency vaccine, which has widely applying prospect with little side effect, therefore reducing immune labor, material and financial ability.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, in particular to an inactivated foot-and-mouth disease type A vaccine. Background technique [0002] Foot-and-mouth disease is an acute, febrile, highly contagious animal disease that can spread quickly and over long distances caused by foot-and-mouth disease virus. There are as many as 70 species of animals. The outbreak of foot-and-mouth disease will seriously affect a country's economic development, international trade, social stability and international reputation. In 1997, foot-and-mouth disease broke out in Taiwan, my country, which led to the closure of pig farming and related industries, 700,000 people were unemployed, and the total economic loss reached 8 billion US dollars. In 2001, foot-and-mouth disease first broke out in the UK, causing direct losses of hundreds of millions of pounds, but the indirect losses of foreign trade and related industries amounted to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/135A61P31/14
Inventor 王永录张永光方玉珍蒋守田刘力宽潘丽吕建亮
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products