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Segmented intestine targeted preparation of animal skin glue collagen polypeptide and method of preparing the same

A technology of colon targeting and animal skin glue, applied in medical raw materials derived from arthropods, medical raw materials derived from molluscs, plant raw materials, etc., can solve the pain of patients, no research reports, collagen can not be fully absorbed, etc. question

Inactive Publication Date: 2008-02-27
李立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are three existing ways to utilize animal skin collagen polypeptides: ① as an auxiliary material for cosmetics, because the effective amount absorbed through the skin is very small, the collagen directly applied to the skin surface cannot be fully absorbed, and its nutrition and beauty features are greatly discounted
② Taking collagen oral liquid or tablets, because it enters the human digestive tract and reaches the stomach and small intestine after oral administration, it is destroyed and metabolized by gastric enzymes and pancreatic enzymes, and the active function of collagen and its hydrolyzate is basically lost. The effect is not ideal
③Injection of collagen nutrient solution, it is obvious that acupuncture injection brings pain to the patient
At present, there is no colon-targeting preparation of animal skin collagen polypeptide in the domestic market, and there is no research report on this preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take by weighing spare 20 grams of animal skin collagen polypeptide freeze-dried powder and 10 grams of Lycium barbarum polysaccharide, mix into compound medicine powder, put in the centrifugal coating granulator, spray mass concentration (g / mL) again and be 50% sucrose syrup moistening Wet, blow dry at 40-70°C for 3-5 hours to prepare pellet cores of 60-80 mesh. Use ethanol solution with a mass concentration (g / mL) of 3% povidone K30 as a binder, spray powder to the pellet core from a powder feeder, so that the pellet core becomes a pellet of 500-800 μm, dry and sieve , that is to obtain the drug-containing micropill, wherein the weight percentage of each component is controlled as follows: 60% of compound drug powder, 25% of sucrose, and 15% of povidone K30.

[0030] Weigh 60 grams of acrylic resin S100, add it to 800 milliliters of 80% ethanol solution, stir to dissolve, then add 7 grams of triethyl citrate and 12 grams of talcum powder in turn, stir and mix, and pas...

Embodiment 2

[0033] Take by weighing spare 25 grams of animal skin collagen polypeptide freeze-dried powder and 5 grams of Lycium barbarum polysaccharide, mix into compound medicinal powder, put in the centrifugal coating granulator, spray mass concentration (g / mL) again and be 50% sucrose syrup moistening Wet, blow dry at 40-70°C for 3-5 hours to prepare pellet cores of 60-80 mesh. Use the ethanol solution with a mass concentration (g / mL) of 3% povidone K30 as a binder, spray powder to the pellet core from a powder feeder, so that the pellet core becomes a pellet of 100-500 μm, dry and sieve , to obtain drug-containing pellets. The percentage by weight of each component is controlled as follows: 92% of compound medicinal powder, 5% of sucrose, and 303% of povidone K.

[0034] Weigh 60 grams of acrylic resin, wherein the weight ratio of acrylic resin S100 and acrylic resin L100 is 1:1.5, add it to 800 milliliters of 80% ethanol solution, stir and dissolve, then add 11 grams of triethyl ci...

Embodiment 3

[0037]Take by weighing spare 160 grams of animal skin collagen polypeptide freeze-dried powder and 6 grams of vitamin E, mix to form compound medicinal powder, put in the centrifugal coating granulator, spray mass concentration (g / mL) again and be 50% sucrose syrup moistening Wet, blow dry at 40-70°C for 3-5 hours to prepare pellet cores of 60-80 mesh. Use ethanol solution with a mass concentration (g / mL) of 3% povidone K30 as a binder, spray powder to the pellet core from a powder feeder, so that the pellet core becomes a pellet of 800-1000 μm, dry and sieve , to obtain drug-containing pellets. The weight percentage of each component is controlled as follows: 80% of compound medicinal powder, 15% of sucrose, and 305% of povidone K.

[0038] Weigh 600 grams of acrylic resin, wherein the weight ratio of acrylic resin S100 and acrylic resin L100 is 1:1.5, add it to 10,000 milliliters of 80% ethanol solution, stir and dissolve, then add 70 grams of triethyl citrate and 120 grams...

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Abstract

The invention provides a colon specific targeting preparation of animal skin collagen polypeptides and its preparing process, wherein the preparation is prepared through coating the drug-containing micro-pellets containing animal skin collagen polypeptides components with colon targeting coating liquid, or directly loading the drug-containing micro-pellets into the shells of the colon targeting capsule. The preparation provided by the invention can make the colon release drugs enter blood circulation through colon, thereby avoiding metabolism destruction of the conventional oral preparation peptides drugs on the stomach, as a result, the therapeutic action of the drugs can be sufficiently exploited.

Description

technical field [0001] The invention relates to a colon-targeting preparation, in particular to a colon-targeting preparation of animal skin collagen polypeptide and a preparation method thereof. Background technique [0002] The biological activity of animal skin collagen polypeptide is extremely high, and it has a variety of important biological effects and physiological functions, and is called "skin soft gold". It is related to the growth, division, differentiation, proliferation and migration of skin cells. It can provide skin nutrients, delay skin aging, promote skin surface repair, increase the water storage function of skin tissue cells, enhance and maintain good elasticity of skin, and delay skin aging. , strong tendons and bones, UFA hair care, physical enhancement and other advantages. [0003] However, there are three existing ways to utilize animal skin collagen polypeptides: ① as an auxiliary material for cosmetics, because the effective amount absorbed throug...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K9/16A61K9/48A61K47/12A61K47/32A61K47/38A61P17/16A61K36/896A61K35/56A61K31/714A61K31/355A61K35/618A61K35/64
Inventor 李立吕应年李延平
Owner 李立
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