Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition of skin external application containing rose extract and epigallocatechin gallate(egcg)

A technology of epigallocatechin and gallate, applied in the field of skin external composition, can solve problems such as being easily oxidized and decomposed, and achieve excellent and long-lasting effect of improving skin wrinkles

Inactive Publication Date: 2008-01-23
AMOREPACIFIC CORP
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, because EGCG has a polyphenolic chemical structure and has a strong antioxidant effect, it is easy to react in an external environment such as air, especially react with oxygen, heat and light, so it is extremely easy to be oxidized and decomposed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0011] The preparation method of the water-stable EGCG capsule composition used in the present invention includes the following steps: mixing a hydrophilic solvent at room temperature; EGCG; a positive polymer, a negative polymer, or a mixture thereof; an antioxidant; and a water-insoluble polymer , Amphiphilic polymers, or their mixtures; and

[0012] Water, a hydrophilic solvent, or a mixture thereof is added to the above mixture to prepare a capsule.

[0013] Another preparation method of the water-stable EGCG capsule composition used in the present invention includes the following steps: mixing a hydrophilic solvent at room temperature; EGCG; and a water-insoluble polymer, an amphiphilic polymer, or a mixture thereof;

[0014] Adding water, a hydrophilic solvent, or a mixture thereof to the above mixture to dissolve the mixture; and

[0015] Mix the positive polymer, negative polymer, or their mixture into the dissolved mixture.

[0016] In the above two methods, based on the ...

experiment Embodiment 1

[0032] Experimental Example 1 Effect on collagen biosynthesis of human skin cells

[0033] Human fibroblasts were cultured in a 24-well microculture plate, and their medium was changed to a medium containing the substances in Table 2. When cultured for 3 days, 0.5 ml of DMEM medium containing 10% fetal bovine serum (FBS) was added to each well, and 10 μCi of L[2,3,4,5-3H]-proline was added to it. After 24 hours, the medium and cells contained in each well were tilted, and a 5% trichloroacetic acid (TCA) solution was added. Then divide each sample into two test tubes, add 1 unit / μl of type I collagenase to one test tube of each pair of test tubes, and incubate at 37°C for 90 minutes; store the other test tube at 4°C. Then, 0.05 ml of 50% TCA was added to each test tube, the test tube was placed at 4° C. for 20 minutes, and then each test tube was centrifuged at 12,000 revolutions per minute (rpm) for 10 minutes. The supernatant and sediment of each group were processed with a Liqui...

Embodiment 1-4 and comparative example 1-5

[0040] According to the composition in Table 3 below, the cream formulations of Examples 1-4 and Comparative Examples 1-5 were prepared. In Table 3, the rose extract was obtained from the leaves, stems and roots of the rose.

[0041] table 3

[0042] Material

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a composition of skin external application comprising rose extracts and epigallocatechin gallate (EGCG) as effective ingredients, more particularly to a composition of skin external application that contains rose extracts and EGCG, thereby promoting the synthesis of collagen fiber to promote superior skin elasticity and skin wrinkle improvement with long-lasting effect.

Description

Technical field [0001] The present invention relates to a composition for external use on skin, which contains epigallocatechin gallate (EGCG) and rose extract. More specifically, the present invention relates to a skin external composition containing EGCG and rose extract, which promotes collagen biosynthesis, thereby producing long-lasting excellent skin elasticity and skin wrinkle improvement. Background technique [0002] Human skin acts as a primary protective barrier to protect vital organs of the human body from external stimuli, such as changes in temperature and humidity, ultraviolet rays and pollutants. However, when the skin ages, the secretion of various hormones that regulate metabolism will decrease, and the function and cell viability of immune cells will also decrease. In addition, due to the increase of ultraviolet light and oxygen free radicals caused by pollution such as destruction of the ozone layer, physical and chemical irritation and stress are generated, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61Q19/00
CPCA61K8/97A61Q19/08A61K8/498A61K8/9789A61P17/00
Inventor 李和俊曹濬喆韩相勋
Owner AMOREPACIFIC CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com