Substituted benzyl ethylene derivant and method of preparing the same and use thereof

Abstract

A substituted benzene propylene derivative and the salt are provided, which is that the phenylacrylate substituted by the corresponding group gains the correspondingly substituted phenylallyl compound through the deoxidization of the lithium aluminium hydride and the aluminium trichloride compound. The invention has certain selective cytotoxicity activeness compound from the natural erucic based alcohol compound and has low toxic effect on the normal cells, while the compounds reconstructed by structure and the important midbodies all have better cytotoxicity activeness and can be prepared inthe drugs preventing and curing the tumor diseases. The prepared drugs contain the drug excipients or carriers allowed by the preparation. The drug preparation is in a form of liquid, solid, aerial fog spray, drop, gelatin pearl, nano, controlled release and sustained-release preparation. The compound related to by the invention has simple synthetic method and lower cost, therefore having feasible marketalization prospect. The invention has the above general formula.

Description

Technical field The present invention relates to the field of organic chemistry, in particular to the preparation method of substituted phenylpropene derivatives, and the series of compounds on six tumor cell lines, such as human prostate cancer cells (PC-3) and nasopharyngeal cancer cells ( CNE), oral epithelial cancer cell line (KB), human lung cancer cell (A549), human liver cancer cell (BEL-7404), and human cervical cancer cell (Hela) have tumor cell growth inhibitory activity. Such compounds are found to have certain activity of inhibiting the growth of tumor cells and can be expected to be used as anti-tumor drugs. Background technique At present, due to environmental pollution and other problems brought about by industrial development, the quality of human living environment is declining, and the incidence and mortality of tumor diseases are also increasing. However, specific drugs for the treatment of tumor diseases are not satisfactory, and the low selectivity of cyto...

AI Technical Summary

Problems solved by technology

However, the specific drugs for the treatment of tumor diseases are not satisfactory, and the malignant killing of normal cells caused by the low selectivity of cytotoxic drugs currently used in anti-tumor clinics limits the general applicability of such drugs

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