Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Quantitative nano aerosol and method of manufacturing the same

An aerosol and nano-technology, applied in the field of nano-aerosol, can solve the problems of poor dispersion of drug particles and low lung delivery efficiency

Inactive Publication Date: 2008-01-23
NANTONG RUIKANGDA BIOTECH CO LTD
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of poor dispersibility of drug particles and low efficiency of lung delivery in existing quantitative micron inhalation aerosols, the present invention provides a nanoparticle of chemical drugs and biomolecules, and the quantitative nanoaerosol prepared by using the nanoparticle Agents and their preparation methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quantitative nano aerosol and method of manufacturing the same
  • Quantitative nano aerosol and method of manufacturing the same
  • Quantitative nano aerosol and method of manufacturing the same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0076] Aerosol preparation

[0077] According to the requirements of conventional treatment and the type of medicine, the amount of chemical medicine or biomolecule contained in each aerosol is usually 0.01mg-2mg, for example, each dose of albuterol is 100-200μg. A certain amount of the mixture of nano drug particles and surfactant is taken and placed in an aerosol can. Add a small amount of low-alkane such as n-heptane to dissolve the surfactant and disperse the nano drug particles, and then seal with a quantitative valve (100 μl). Then inject the fluoroalkane HFC134a to obtain a uniformly dispersed and extremely stable suspension (Figure 4A). After standing for four months, neither sediment nor floating matter appeared (Fig. 4B). Therefore, very stable aerosols can be successfully prepared using nano-drug particles, and their good dispersion state shows their excellent ability in pulmonary drug delivery.

[0078] Testing for Pulmonary Drug Delivery

[0079] Pulmonary dru...

Embodiment 1

[0083] Lecithin is dissolved in isopropanol to make a surfactant solution (mass ratio is lecithin: isopropanol=1:3). Add 56.3mL of surfactant solution into 43.5mL of isooctane, oscillate evenly, and let stand for 30 minutes. Then add 23.8mL of 15% (mass percentage) salbutamol aqueous solution, shake vigorously, mix evenly, make it become microemulsion.

[0084] The standard operating procedure for the preparation of albuterol nanoparticles is as follows. The spray dryer sprays and dries the above-mentioned microemulsion under standard working conditions. After completion, use n-heptane to dissolve and recover the dry matter deposited in the spray chamber, cyclone centrifuge and collector. Dry naturally at room temperature, remove the n-heptane, and obtain a dry mixture containing nano albuterol particles, the average particle diameter of which is close to 20nm.

[0085] Take 30 mg of the mixture (containing 7.5 mg of drug) and put it into an aerosol can, and add 1 mL of n-h...

Embodiment 2

[0087] In Example 1, 30 mg (containing 7.5 mg of drug) was weighed from the mixture containing nano-medicine particles prepared by spray drying and put into an aerosol can, and 1 mL of n-pentane was injected to uniformly disperse the nano-medicine particles in the in. Seal it with a 100 μL metering valve, and then inject 6.5 mL of propellant HFC134a to obtain an aerosol in a fluid in which nano drug particles are uniformly dispersed. This 100μg / spray nano-aerosol can maintain a very stable dispersion state. The microparticle ratio (particle size<5.8 μm) was determined to be 61% by lung model.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a nanometer grain and rationed nanometer aerosol utilizing the nanometer grain and their preparation method. With comprehensive microemulsion technology and fast drying technology, prepare a plurality of chemical drugs and biologic particles into nanometer grain, so as to enhance the transfer efficiency via lung intake. To be specific, evenly distribute the liquid for dissolving the drug in another non-mixing solvent under the action of surfactant with microemulsion technology. Then, evaporate all the liquid with fast drying technology to get the nanometer grain of drug. The nanometer grain of drug can evenly disperse in a fluid with propellent, so as to get the nanometer preparation of aerosol. The nanometer preparation has stable transfer capacity for the lung intake of drug and can be applied to drugs with lung transfer, oral transfer or nostril transfer.

Description

technical field [0001] The invention relates to a nano particle, a quantitative nano aerosol using the nano particle and a preparation method thereof. In detail, the present invention relates to a nanoparticle of chemical drugs and biomolecules, a quantitative nano-aerosol of chemical drugs and biomolecules, and a preparation method thereof, by which numerous chemical drugs and biomolecules can be prepared into nano particles and can be used to prepare nano-aerosols. Background technique [0002] Traditionally, the use of lung inhalation to achieve drug delivery is mainly used to treat local diseases, such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, pneumonia, etc. In recent years, pulmonary inhalation has developed into a new drug delivery method to treat systemic diseases, such as diabetes, migraine, osteoporosis, acrosclerosis, and even anesthesia. In inhalable formulations, the deposition of drug particles in the respiratory system is closely rel...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/12A61K47/06A61K47/08A61K47/14A61P11/00
Inventor 鲁明华
Owner NANTONG RUIKANGDA BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com