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Medicine for treating lung carbuncle and its preparation method

A technology for medicine and pulmonary abscess, which is applied in the field of medicine for treating pulmonary abscess and its preparation, can solve the problems of insufficient research on Weigan decoction, missing active ingredients, and reducing pharmacological effects, etc.

Active Publication Date: 2008-01-16
广东星昊药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional extraction method of reed stem soup is decoction. At present, there are not many in-depth studies on reed stem soup. The four traditional Chinese medicines in reed stem soup, reed root contain a large amount of reed root polysaccharide, and coix seed contains coix seed Polysaccharides and coix seed nectarines contain amygdalin. The traditional extraction method simply boils the four traditional Chinese medicines in water and takes them, which leads to the blurring of the active ingredients. Simply proposing water-soluble ingredients will inevitably lead to many omissions. Active ingredients of other polarity reduce the pharmacological effects of this prescription

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Preparation of main drug:

[0055] a. Grind 500g coix seed medicinal material, add 5 times the amount of water to soak for 1 hour, extract by steam distillation for 2 hours, collect the volatile oil, and clathrate with 20 times the amount of hydroxypropyl-β-cyclodextrin to obtain the active ingredient A; Keep the aqueous solution and medicinal residues for use;

[0056] b. Grind 1000g reed rhizome medicinal material, put it in an extraction container with the dregs in step a, add 75% ethanol to soak for 24 hours, recover ethanol, add 6 times the amount of water to decoct for 1 hour, extract once, and step The aqueous solution in a is combined with the aqueous solution extracted this time, filtered, the filtrate is concentrated under reduced pressure to 1 / 8 volume, 20% ethanol is added to the concentrated solution, left at room temperature for 6 hours, suction filtered, and the precipitate is collected; Add ethanol to make the alcohol content reach 50%, leave it at ...

Embodiment 2

[0068] (1) Preparation of main drug:

[0069] a. Grind 250g coix seed medicinal material, add 6 times the amount of water to soak for 1.5 hours, extract by steam distillation for 2.5 hours, collect the volatile oil, and clathrate with 25 times the amount of hydroxypropyl-β-cyclodextrin to obtain the active ingredient A; Keep the aqueous solution and medicinal residues for use;

[0070] b. Grind 500g reed rhizome medicinal material, put it in an extraction container with the dregs in step a, add 80% ethanol to soak for 30 hours, recover ethanol, add 7 times the amount of water to decoct for 1.5 hours, extract twice, and step The aqueous solution in a is combined with the aqueous solution extracted this time, filtered, the filtrate is concentrated under reduced pressure to 1 / 9 volume, 25% ethanol is added to the concentrated solution, left at room temperature for 7 hours, suction filtered, and the precipitate is collected; Add ethanol to make the alcohol content reach 55%, leav...

Embodiment 3

[0082] (1) Preparation of main drug:

[0083] a. Grind 1000g coix seed medicinal material, add 10 times the amount of water to soak for 3 hours, extract by steam distillation for 4 hours, collect the volatile oil, and clathrate with 50 times the amount of hydroxypropyl-β-cyclodextrin to obtain the active ingredient A; Keep the aqueous solution and medicinal residues for use;

[0084] b. Grind 2000g reed rhizome medicinal material, put it in an extraction container with the dregs in step a, add 95% ethanol to soak for 48 hours, recover ethanol, add 10 times the amount of water to decoct for 3 hours, extract twice, and The aqueous solution in a is combined with the aqueous solution extracted this time, filtered, the filtrate is concentrated under reduced pressure to 1 / 10 volume, 45% ethanol is added to the concentrated solution, left at room temperature for 12 hours, suction filtered, and the precipitate is collected; Add ethanol to make the alcohol content reach 70%, leave it ...

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Abstract

The invention discloses the medicine and the preparation method for treating the pulmonary abscess. The invention firstly extract the ingredient of the coix seed oil in the coix seed by steam distillation, and ensures the stability of the ingredient of the volatile oil by the hydroxypropyl-Beta-cyclodextrin inclusion, then the distilled herb residues and the pharagmitis rhizoma are put into the container and are soaked by ethanol, the ethanol solution is recovered, and the polysaccharide mixture is extracted by hot water; and the peach seed and Chinese waxgourd semen are put into the hot water for extracting, so the effective ingredients can be obtained. The chief drug in the medicine of the invention can be made by mixing the effective ingredients extracted by the three steps, and then the solid preparation can be made by mixing the chief drug fixes with the proper pharmaceutical excipient. The extraction technique of the invention adopts the respective extraction method to better extract the effective ingredients of the four crude drugs in the prescription, thus the pharmacological action can be improved and the taking dosage can be reduced.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a medicine for treating pulmonary abscess and a preparation method thereof. Background technique [0002] Pulmonary abscess belongs to the traditional Chinese medical science theory, which is caused by heat and toxin blocking the lungs, phlegm and blood stasis. Phlegm heat blocks the lungs, and if the qi is not cleared, it will cause coughing and excessive phlegm; "Internal Classics" says: "If the heat is excessive, the meat will rot, and if the meat rots, it will form pus." When it dissipates, the blood will rot and the flesh will rot, and it will become a lung abscess; the carbuncle and pus are ruptured and come out by throat, so you cough and spit out foul-smelling yellow phlegm, pus and blood; Slippery numbers are signs of phlegm heat. Control when clearing the lung and resolving phlegm, removing blood stasis and draining pus. [0...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/16A61K9/20A61K9/48A61P11/00
Inventor 张树祥阚迎昕
Owner 广东星昊药业有限公司
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